Nonstructural protein
From Proteopedia
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<StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'> | <StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'> | ||
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[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see<br /> | [[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see<br /> | ||
*[[User:Michael Strong/H1N1/NS]]<br /> | *[[User:Michael Strong/H1N1/NS]]<br /> | ||
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For NS1 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP1]].<br /> | For NS1 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP1]].<br /> | ||
| + | For NS2 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP2]].<br /> | ||
For NS3 of SARS-CoV-2 see [[SARS-CoV-2 enzyme Papain-like]].<br /> | For NS3 of SARS-CoV-2 see [[SARS-CoV-2 enzyme Papain-like]].<br /> | ||
| + | For NS4 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP4]].<br /> | ||
| + | For NS6 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP6]].<br /> | ||
For NS7 or '''replicase polyprotein 1ab light chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP7]].<br /> | For NS7 or '''replicase polyprotein 1ab light chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP7]].<br /> | ||
For NS8 or '''replicase polyprotein 1ab heavy chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP8]].<br /> | For NS8 or '''replicase polyprotein 1ab heavy chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP8]].<br /> | ||
For NS9 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP9]].<br /> | For NS9 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP9]].<br /> | ||
For NS10 or '''replicase polyprotein 1ab''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP10]].<br /> | For NS10 or '''replicase polyprotein 1ab''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP10]].<br /> | ||
| - | For NS12 of SARS-CoV-2 see also [[Vitamin B12 may inhibit | + | For NS12 of SARS-CoV-2 see also [[Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 vi]].<br /> |
For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see [[SARS-CoV-2 enzyme RdRp]].<br /> | For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see [[SARS-CoV-2 enzyme RdRp]].<br /> | ||
SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called '''replication-transcription complex'''.<br /> | SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called '''replication-transcription complex'''.<br /> | ||
Current revision
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References
- ↑ Zhu Z, Shi Z, Yan W, Wei J, Shao D, Deng X, Wang S, Li B, Tong G, Ma Z. Nonstructural protein 1 of influenza A virus interacts with human guanylate-binding protein 1 to antagonize antiviral activity. PLoS One. 2013;8(2):e55920. doi: 10.1371/journal.pone.0055920. Epub 2013 Feb 6. PMID:23405236 doi:http://dx.doi.org/10.1371/journal.pone.0055920
- ↑ Wang M, Ng KK, Cherney MM, Chan L, Yannopoulos CG, Bedard J, Morin N, Nguyen-Ba N, Alaoui-Ismaili MH, Bethell RC, James MN. Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem. 2003 Mar 14;278(11):9489-95. Epub 2002 Dec 30. PMID:12509436 doi:10.1074/jbc.M209397200
