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7o1h
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7o1h is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Hybrid-2R quadruplex-duplex with (-p-p-l) topology and 3 syn residues== | |
| + | <StructureSection load='7o1h' size='340' side='right'caption='[[7o1h]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O1H FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o1h OCA], [https://pdbe.org/7o1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o1h RCSB], [https://www.ebi.ac.uk/pdbsum/7o1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o1h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Canonical G-quadruplexes can adopt a variety of different topologies depending on the arrangement of propeller, lateral, or diagonal loops connecting the four G-columns. A novel intramolecular G-quadruplex structure is derived through inversion of the last G-tract of a three-layered parallel fold, associated with the transition of a single propeller into a lateral loop. The resulting (3+1) hybrid fold features three syn.anti.anti.anti G-tetrads with a 3'-terminal all- syn G-column. Although the ability of forming a duplex stem-loop between G-tracts seems beneficial for a propeller-to-lateral loop rearrangement, unmodified G-rich sequences resist folding into the new (3+1) topology. However, refolding can be driven by the incorporation of syn -favoring guanosine analogs into positions of the fourth G-stretch. The presented hybrid-type G-quadruplex structure as determined by NMR may provide for an additional scaffold in quadruplex-based technologies. | ||
| - | + | Expanding the Topological Landscape by a G-Column Flip of a Parallel G-Quadruplex.,Mohr S, Jana J, Vianney YM, Weisz K Chemistry. 2021 May 6. doi: 10.1002/chem.202101181. PMID:33955615<ref>PMID:33955615</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7o1h" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mohr S]] | ||
| + | [[Category: Vianney YM]] | ||
| + | [[Category: Weisz K]] | ||
Current revision
Hybrid-2R quadruplex-duplex with (-p-p-l) topology and 3 syn residues
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