Induced fit

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[[Image:Induced fit.gif|frame|Morph of hexokinase in the open [[3o80]] and glucose-bound closed [[3o8m]] conformation. For reference, glucose (purple) is shown throughout the morph. Two views are shown, an overview as spacefill and a detail of the binding site in wireframe.]]
[[Image:Induced fit.gif|frame|Morph of hexokinase in the open [[3o80]] and glucose-bound closed [[3o8m]] conformation. For reference, glucose (purple) is shown throughout the morph. Two views are shown, an overview as spacefill and a detail of the binding site in wireframe.]]
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[[Induced fit]] describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classical example of induced fit is binding of glucose to hexokinase, depicted in a morph between [[3o8m]] and [[3o80]] below.
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[[Induced fit]] describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classic example of induced fit is binding of glucose to hexokinase, depicted in a morph between [[3o8m]] and [[3o80]] in the picture at right.
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<StructureSection load='' size='350' side='right' caption='' scene=''>
<StructureSection load='' size='350' side='right' caption='' scene=''>
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This is a [[morphs|morph]] of the <scene name='31/318562/Hexokinase/1'>closed and open form of hexokinase</scene> (be patient when loading this). The first and the last frame of the animation are models based on crystallographic data while the intermediate states are somewhat arbitrary, but chosen to show a smooth transition between conformations.
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This is a [[morphs|morph]] of the <scene name='31/318562/Hexokinase/3'>closed and open form of hexokinase</scene> (be patient when loading this). The first and the last frame of the animation are models based on crystallographic data while the intermediate states are somewhat arbitrary, but chosen to show a smooth transition between conformations.
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<jmol>
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<jmolRadioGroup>
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<item>
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<script>anim off;model 1</script>
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<text>Open</text>
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</item>
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<item>
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<script>anim off;model 11</script>
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<text>Closed</text>
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</item>
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<item>
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<script>anim on;</script>
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<text>Animated</text>
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<checked>true</checked>
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</item>
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</jmolRadioGroup>
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</jmol>
</StructureSection>
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Current revision

Morph of hexokinase in the open 3o80 and glucose-bound closed 3o8m conformation. For reference, glucose (purple) is shown throughout the morph. Two views are shown, an overview as spacefill and a detail of the binding site in wireframe.
Morph of hexokinase in the open 3o80 and glucose-bound closed 3o8m conformation. For reference, glucose (purple) is shown throughout the morph. Two views are shown, an overview as spacefill and a detail of the binding site in wireframe.

Induced fit describes a conformational change in a protein when it binds a ligand, in contrast to a lock-and-key model of ligand binding. A classic example of induced fit is binding of glucose to hexokinase, depicted in a morph between 3o8m and 3o80 in the picture at right.


Contents

History of the concept

Induced fit was suggested by Koshland in 1958 [1], providing an alternative to the lock-and-key binding model that Emil Fischer proposed in 1899 [2].

Interactive examples

Drag the structure with the mouse to rotate

See Also


References

  1. ↑ doi: https://dx.doi.org/10.1002/anie.199423751
  2. ↑ doi: https://dx.doi.org/10.1002/cber.18940270364

Proteopedia Page Contributors and Editors (what is this?)

Karsten Theis, Eric Martz, Eran Hodis

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