7en2
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7en2 is ON HOLD Authors: Wang, J.L., Wang, Z.J. Description: Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module-afte...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module-after-condensation, condensation== | |
| - | + | <StructureSection load='7en2' size='340' side='right'caption='[[7en2]], [[Resolution|resolution]] 3.78Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7en2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EN2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.78Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene></td></tr> |
| - | [[Category: Wang | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7en2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7en2 OCA], [https://pdbe.org/7en2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7en2 RCSB], [https://www.ebi.ac.uk/pdbsum/7en2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7en2 ProSAT]</span></td></tr> |
| - | [[Category: Wang | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PCHE_PSEAE PCHE_PSEAE] Involved in the biosynthesis of the siderophore pyochelin (PubMed:9846750, PubMed:11208777). Accepts salicylate activated by PchD at the first peptidyl carrier domain (ArCP), and activates and fixes one molecule of cysteine at the second peptidyl carrier domain (PCP1) via a thioester linkage to the phosphopanthetheine moiety (By similarity). Then catalyzes the condensation reaction between the salicylate bound to the first site and the cysteine bound to the second site, and the cyclization of the cysteine to form the salicyl-thiazolinyl-S-PCP1 intermediate at the second site (By similarity). When this intermediate is released by the action of a thioesterase, it produces the antifungal antibiotic dihydroaeruginoic acid (Dha or hydroxyphenyl-thiazolinyl-carboxylate) (PubMed:11208777).[UniProtKB:A0A0H2ZGB9]<ref>PMID:11208777</ref> <ref>PMID:9846750</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa PAO1]] | ||
| + | [[Category: Wang JL]] | ||
| + | [[Category: Wang ZJ]] | ||
Current revision
Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module-after-condensation, condensation
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