Progestogens
From Proteopedia
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| - | <StructureSection load='2w8y' size=' | + | <StructureSection load='2w8y' size='300' side='right' caption='Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry [[2w8y]])' scene='78/780972/Cv/2'> |
'''Progesterone''' | '''Progesterone''' | ||
| - | *[[Progesterone receptor]] | + | |
| - | Progesterone is a negative allosteric modulator of [[nicotinic acetylcholine receptors]], and a potent antagonist of the [[mineralocorticoid receptor]]. | + | <scene name='89/895670/Cv/7'>Progesterone</scene> (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. |
| + | *[[Progesterone receptor]]. <scene name='89/895670/Cv/8'>Human progesterone receptor ligand-binding domain bound with progesterone</scene> ([[1a28]]). Water molecules are shown as red spheres. | ||
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| + | *Progesterone is a negative allosteric modulator of [[nicotinic acetylcholine receptors]], and a potent antagonist of the [[mineralocorticoid receptor]]. | ||
*[[Hydroxysteroid dehydrogenase]], 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 17-β HSD is involved in the conversion of androstenedione to testosterone. | *[[Hydroxysteroid dehydrogenase]], 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 17-β HSD is involved in the conversion of androstenedione to testosterone. | ||
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