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Neprilysin

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== Relevance ==
== Relevance ==
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NEP signaling has also been implicated in cardiovascular disease.<ref>PMID: 21046489</ref> NEP level increases in Alzheimer's disease patients<ref>PMID: 19606063</ref>. NEP inhibitors are tested as analgesics and anti-hypertensive agents.
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NEP signaling has also been implicated in cardiovascular disease.<ref>PMID: 21046489</ref> NEP level increases in Alzheimer's disease patients<ref>PMID: 19606063</ref>. NEP inhibitors like [[Sacubitril]] and [[Sacubitril/valsartan]] are tested as analgesics and anti-hypertensive agents.
== Structural highlights ==
== Structural highlights ==

Current revision

Structure of glycosylated human neprilysin extracellular domain complex with phosphoramidon and Zn+2 ion (grey) (PDB entry 1dmt)

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Michal Harel, Alexander Berchansky, Brenton Horne

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