Journal:Acta Cryst F:S2053230X21013595
From Proteopedia
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| - | - | + | <StructureSection load='' size='450' side='right' scene='90/900077/Cv/2' caption=''> |
| + | ===Crystal structure of a hypothetical protein from ''Giardia lamblia''=== | ||
| + | <big>Dylan Beard, Seonna Bristol, Kayla Cosby, Amber Davis, Courtney Manning, Lionel Perry, Lauren Snapp, Arian Toy, Kayla Wheeler, Jeremy Young, Bart L Staker, David Dranow, Jan Abendroth, Sandhya Subramanian, Thomas E Edwards, Peter J Myler, and Oluwatoyin A. Asojo</big> <ref>doi: 10.1107/S2053230X21013595</ref> | ||
| + | <hr/> | ||
| + | <b>Molecular Tour</b><br> | ||
| + | Giardiasis or traveler's diarrhea can be fatal to the young, elderly, or immunocompromised. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined the structures of potential drug targets from ''Giardia lamblia''. Some of these proteins are hypothetical proteins that share < 30% sequence identity or less to proteins with known structure (see static image below). | ||
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| + | [[Image:Figure3newa.png|left|450px|thumb|Despite the low sequence similarity the hypothetical protein is a prototypical YjgF/YER057c/UK114 endoribonuclease]] | ||
| + | {{Clear}} | ||
| + | The atomic resolution structure of a 15.6 kDa protein was determined by molecular replacement (PDB entry [[3i3f]]). The structure has <scene name='90/900077/Cv/6'>the 2-layer alpha-beta-sandwich topology</scene> observed in the prototypical endoribonucleases L-PSP with conserved allosteric active sites containing small molecules from the crystallization solution. {{Template:ColorKey_Helix}}, | ||
| + | {{Template:ColorKey_310Helix}}, | ||
| + | {{Template:ColorKey_PiHelix}}, | ||
| + | {{Template:ColorKey_Strand}}, | ||
| + | {{Template:ColorKey_Loop}}, | ||
| + | {{Template:ColorKey_Turn}}. <scene name='90/900077/Cv/4'>Superposed GilaA.00312.a trimer to closest structures</scene>. Chains A, B, and C of GilaA.00312.a trimer are colored in <span class="bg-lightgreen">green</span>, <span class="bg-lightcyan">cyan</span>, and <b><span class="text-magenta">magenta</span></b>, respectively. The closest structures are colored in gray. These studies are part of ongoing studies to identify proteins that could be targeted for rational drug discovery for giardiasis. This paper is an educational collaboration between Hampton University (an HBCU) and the Seattle Structural Genomics Center for Infectious Disease (SSGCID). | ||
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| + | '''PDB reference:''' hypothetical protein from ''Giardia lamblia'', [[3i3f]]. | ||
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| + | <b>References</b><br> | ||
| + | <references/> | ||
| + | </StructureSection> | ||
| + | __NOEDITSECTION__ | ||
Current revision
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This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
