Platelet glycoprotein

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{{ABSTRACT_PUBMED_12183630}}
{{ABSTRACT_PUBMED_12183630}}
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*'''Platelet glycoprotein Ib alpha''' has a role in the adhesion and migration of leukocytes on vascular thrombus<ref>PMID:10899906</ref>.
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*'''Platelet glycoprotein 4''' or '''CD36''' functions as a receptor for thrombospondin and collagen <ref>PMID:2665870</ref>.
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*'''Platelet glycoprotein 6''' ha a role in collagen-induced platelet activation<ref>PMID:15381385</ref>.
==Disease==
==Disease==
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[[1m10]] is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M10 OCA].
[[1m10]] is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M10 OCA].
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==Platelet glycoprotein 4 ==
 
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'''Platelet glycoprotein 4''' or '''CD36''' functions as a receptor for thrombospondin and collagen <ref>PMID:2665870</ref>.
 
</StructureSection>
</StructureSection>
==3D structures of platelet glycoprotein==
==3D structures of platelet glycoprotein==
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**[[1gwb]], [[1p9a]], [[1qyy]] – hPGIb von Willenbrand factor binding domain 17-306 - human <BR />
**[[1gwb]], [[1p9a]], [[1qyy]] – hPGIb von Willenbrand factor binding domain 17-306 - human <BR />
**[[1m0z]] – hPGIb von Willenbrand factor binding domain (mutant) <BR />
**[[1m0z]] – hPGIb von Willenbrand factor binding domain (mutant) <BR />
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**[[3rfe]] – hPGIb b chain 26-146<BR />
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**[[3rfe]] – hPGIb b chain 26-146 (mutant)<BR />
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**[[6ejx]] – PGIb a chain von Willenbrand factor binding domain - mouse<BR />
*Platelet glycoprotein Ib complexes
*Platelet glycoprotein Ib complexes
**[[1m10]], [[1sq0]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain (mutant)<BR />
**[[1m10]], [[1sq0]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain (mutant)<BR />
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**[[6xfq]] – hPGIb von Willenbrand factor binding domain + agkisacucetin<BR />
**[[1u0n]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain + botrocetin<BR />
**[[1u0n]] – hPGIb von Willenbrand factor binding domain (mutant) + von Willenbrand factor A1 domain + botrocetin<BR />
**[[3pmh]], [[1gwb]] – hPGIb von Willenbrand factor binding domain (mutant) + thrombin<BR />
**[[3pmh]], [[1gwb]] – hPGIb von Willenbrand factor binding domain (mutant) + thrombin<BR />
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**[[1sq0]] – hPGIb von Willenbrand factor binding domain + peptide inhibitor<BR />
**[[1sq0]] – hPGIb von Willenbrand factor binding domain + peptide inhibitor<BR />
**[[2bp3]] – hPGIb cytoplasmic domain + filamin A rod domain <BR />
**[[2bp3]] – hPGIb cytoplasmic domain + filamin A rod domain <BR />
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**[[6ejx]] – PGIb α chain von Willenbrand factor binding domain - mouse<BR />
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**[[1ook]] – hPGIb a chain + alpha thrombin + peptide<BR />
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**[[4c2a]], [[4c2b]] – hPGIb a chain (mutant) + von Willenbrand factor <BR />
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**[[3p72]] – hPGIb a chain + peptide inhibitor<BR />
*Platelet glycoprotein 4
*Platelet glycoprotein 4
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**[[5lgd]] – hPG4 + PFEMP1 <BR />
**[[5lgd]] – hPG4 + PFEMP1 <BR />
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**[[5ou7]] – hPG6 <BR />
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*Platelet glycoprotein 6
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**[[2gi7]], [5ou7]] – hPG6 <BR />
**[[5ou9]], [[5ou8]] – hPG6 + collagen peptide <BR />
**[[5ou9]], [[5ou8]] – hPG6 + collagen peptide <BR />
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**[[7nmu]] – hPG6 + nanobody <BR />
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**[[7r58]] – hPG6 + antibody <BR />
}}
}}
==Reference==
==Reference==
<ref group="xtra">PMID:12183630</ref><references group="xtra"/>
<ref group="xtra">PMID:12183630</ref><references group="xtra"/>
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<references/>
==See Also==
==See Also==
*[[Leucine-rich repeat]]
*[[Leucine-rich repeat]]

Current revision

Platelet-receptor glycoprotein Ib alpha (blue) involved in Willebrand disease bound to the von Willebrand Factor A1 Domain (green surface), (1m10)

Drag the structure with the mouse to rotate

3D structures of platelet glycoprotein

Updated on 21-July-2024

Reference

  • Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P. Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science. 2002 Aug 16;297(5584):1176-9. PMID:12183630 doi:10.1126/science.107355
  1. ↑ Simon DI, Chen Z, Xu H, Li CQ, Dong Jf, McIntire LV, Ballantyne CM, Zhang L, Furman MI, Berndt MC, López JA. Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med. 2000 Jul 17;192(2):193-204. PMID:10899906 doi:10.1084/jem.192.2.193
  2. ↑ Kunicki TJ. Platelet membrane glycoproteins and their function: an overview. Blut. 1989 Jul;59(1):30-4. PMID:2665870
  3. ↑ Moroi M, Jung SM. Platelet glycoprotein VI: its structure and function. Thromb Res. 2004;114(4):221-33. PMID:15381385 doi:10.1016/j.thromres.2004.06.046

See Also

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