User:Hannah Luchinski/Sandbox 1
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< User:Hannah Luchinski(Difference between revisions)
(New page: ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for you...) |
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| - | = | + | = Human Neurofibromin, 7PGR = |
| - | <StructureSection load=' | + | [[Image:Ribbon_transition_closed.png|400px|left|thumb|Figure 1. The coolest image of this protein EVAH!!!]] |
| - | + | <StructureSection load='7PGR' size='350' frame='true' side='right' caption='Neurofibromin 7PGR' scene=''> | |
| - | + | ||
| + | == Introduction == | ||
| + | [https://en.wikipedia.org/wiki/Neurofibromin_1 Neurofibromin] is a tumor suppressor protein that is coded for by the Neurofibromin 1 gene. | ||
== Function == | == Function == | ||
| + | <ref name="Neurofibromin">PMID:33121128</ref> | ||
| + | == Structural highlights == | ||
| + | |||
| + | === Closed Conformation === | ||
| + | |||
| + | ==== Zinc Stabilized Transition Metal Binding Site ==== | ||
| + | |||
| + | === Open Conformation === | ||
| + | |||
| + | === Sec14-PH and GRD Domains === | ||
| + | <scene name='90/905633/Grd_closed/1'>GRD in the Closed and Sterically Hindered Conformation</scene> | ||
| + | === Arginine Finger === | ||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
| + | <ref name="Ransey">PMID:28504306</ref> | ||
| + | == Student Contributors == | ||
| + | *Hannah Luchinski | ||
| + | *Sophie Mullinix | ||
| + | |||
| - | == Structural highlights == | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Current revision
Human Neurofibromin, 7PGR
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References
- ↑ Bergoug M, Doudeau M, Godin F, Mosrin C, Vallee B, Benedetti H. Neurofibromin Structure, Functions and Regulation. Cells. 2020 Oct 27;9(11). pii: cells9112365. doi: 10.3390/cells9112365. PMID:33121128 doi:http://dx.doi.org/10.3390/cells9112365
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
