7qux

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'''Unreleased structure'''
 
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The entry 7qux is ON HOLD until Paper Publication
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==Crystal structure of P7C8 bound to CK2alpha==
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<StructureSection load='7qux' size='340' side='right'caption='[[7qux]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7qux]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OUT:CARBAMIC+ACID'>OUT</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qux OCA], [https://pdbe.org/7qux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qux RCSB], [https://www.ebi.ac.uk/pdbsum/7qux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qux ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In this work, an iterative cycle of enzymatic assays, X-ray crystallography, molecular modelling and cellular assays were used to develop a functionalisable chemical probe for the CK2alpha/beta PPI. The lead peptide, P8C9, successfully binds to CK2alpha at the PPI site, is easily synthesisable and functionalisable, highly stable in serum and small enough to accommodate further optimisation.
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Authors: Atkinson, E., Iegre, J., Brear, P., Baker, D., Sore, H., Hyvonen, M., Spring, D.
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Development of small cyclic peptides targeting the CK2alpha/beta interface.,Atkinson EL, Iegre J, D'Amore C, Brear P, Salvi M, Hyvonen M, Spring DR Chem Commun (Camb). 2022 Apr 12;58(30):4791-4794. doi: 10.1039/d2cc00707j. PMID:35343996<ref>PMID:35343996</ref>
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Description: Crystal structure of P8C9 bound to CK2alpha
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Spring, D]]
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<div class="pdbe-citations 7qux" style="background-color:#fffaf0;"></div>
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[[Category: Baker, D]]
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== References ==
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[[Category: Hyvonen, M]]
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<references/>
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[[Category: Sore, H]]
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__TOC__
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[[Category: Iegre, J]]
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</StructureSection>
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[[Category: Brear, P]]
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[[Category: Homo sapiens]]
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[[Category: Atkinson, E]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Atkinson E]]
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[[Category: Baker D]]
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[[Category: Brear P]]
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[[Category: Hyvonen M]]
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[[Category: Iegre J]]
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[[Category: Sore H]]
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[[Category: Spring D]]

Current revision

Crystal structure of P7C8 bound to CK2alpha

PDB ID 7qux

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