7u8c

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'''Unreleased structure'''
 
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The entry 7u8c is ON HOLD until Paper Publication
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==Crystal structure of Mesothelin C-terminal peptide-MORAb 15B6 FAB complex==
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<StructureSection load='7u8c' size='340' side='right'caption='[[7u8c]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7u8c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U8C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u8c OCA], [https://pdbe.org/7u8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u8c RCSB], [https://www.ebi.ac.uk/pdbsum/7u8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u8c ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
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== Function ==
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[https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Membrane-anchored forms may play a role in cellular adhesion.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref> Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SignificanceMesothelin (MSLN) is a cell-surface protein that is a popular target for antibody-based therapies. We have identified shed MSLN as a major obstacle to successful antibody therapies and prepared a monoclonal antibody that inhibits shedding and makes very active CAR T cells whose activity is not blocked by shed MSLN and merits further preclinical development.
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Authors: Zhan, J., Esser, L., Xia, D.
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Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin.,Liu X, Onda M, Watson N, Hassan R, Ho M, Bera TK, Wei J, Chakraborty A, Beers R, Zhou Q, Shajahan A, Azadi P, Zhan J, Xia D, Pastan I Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2202439119. doi: , 10.1073/pnas.2202439119. Epub 2022 May 5. PMID:35512094<ref>PMID:35512094</ref>
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Description: Crystal structure of Mesothelin C-terminal peptide-MORAb 15B6 FAB complex
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Xia, D]]
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<div class="pdbe-citations 7u8c" style="background-color:#fffaf0;"></div>
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[[Category: Esser, L]]
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== References ==
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[[Category: Zhan, J]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Esser L]]
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[[Category: Xia D]]
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[[Category: Zhan J]]

Current revision

Crystal structure of Mesothelin C-terminal peptide-MORAb 15B6 FAB complex

PDB ID 7u8c

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