7r3g

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'''Unreleased structure'''
 
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The entry 7r3g is ON HOLD until Paper Publication
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==PROSS optimitzed variant of RhlR (75 mutations) in complex with the synthetic antagonist mBTL==
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<StructureSection load='7r3g' size='340' side='right'caption='[[7r3g]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7r3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R3G FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K5G:4-(3-bromophenoxy)-N-[(3S)-2-oxothiolan-3-yl]butanamide'>K5G</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r3g OCA], [https://pdbe.org/7r3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r3g RCSB], [https://www.ebi.ac.uk/pdbsum/7r3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r3g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RHLR_PSEAE RHLR_PSEAE] Quorum-sensing regulator that controls the expression of multiple virulence factors in response to extracellular signaling molecules called autoinducers (PubMed:7494482, PubMed:8522523, PubMed:15576196). Involved, among others, in the transcriptional regulation of genes that are responsible for rhamnolipid surfactant biosynthesis (PubMed:8144472, PubMed:7604006, PubMed:14526008). Acts by binding to a specific sequence in the rhlAB regulatory region, both in the presence and in the absence of its autoinducer (PubMed:14526008). In the former case it activates transcription of the promoter, whereas in the latter it acts as a transcriptional repressor (PubMed:14526008). Also regulates the expression of the rmlBDAC operon, encoding dTDP-L-rhamnose biosynthetic enzymes, by binding to the rml box in the promoter region (PubMed:22262098). In addition, is involved in the regulation of the production of elastase (lasB) and pyocyanine (PubMed:8144472, PubMed:7604006, PubMed:8522523).<ref>PMID:14526008</ref> <ref>PMID:15576196</ref> <ref>PMID:22262098</ref> <ref>PMID:7494482</ref> <ref>PMID:7604006</ref> <ref>PMID:8144472</ref> <ref>PMID:8522523</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Blankenfeldt W]]
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[[Category: Henke S]]

Current revision

PROSS optimitzed variant of RhlR (75 mutations) in complex with the synthetic antagonist mBTL

PDB ID 7r3g

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