Talk:Methylenetetrahydrofolate reductase
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Textbook chapter on folate reactions: [https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Book%3A_Organic_Chemistry_with_a_Biological_Emphasis_v2.0_(Soderberg)/17%3A_The_Organic_Chemistry_of_Vitamins/17.05%3A_Folate Chapter 17.5] | Textbook chapter on folate reactions: [https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Book%3A_Organic_Chemistry_with_a_Biological_Emphasis_v2.0_(Soderberg)/17%3A_The_Organic_Chemistry_of_Vitamins/17.05%3A_Folate Chapter 17.5] | ||
| - | + | Textbook on ping pong mechanisms: [https://chem.libretexts.org/Bookshelves/Biological_Chemistry/Supplemental_Modules_(Biological_Chemistry)/Enzymes/Enzymatic_Kinetics/Ping-pong_mechanisms Libretext again] | |
1ZP3, 1ZP4, 1ZPT, and 1ZRQ are the E. coli structures with substrate or product bound. | 1ZP3, 1ZP4, 1ZPT, and 1ZRQ are the E. coli structures with substrate or product bound. | ||
The paper is behind a paywall, but here is the link to the abstract: [https://pubs.acs.org/doi/abs/10.1021/bi050533q] | The paper is behind a paywall, but here is the link to the abstract: [https://pubs.acs.org/doi/abs/10.1021/bi050533q] | ||
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| + | Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition<ref>DOI:10.1038/s41467-018-04735-2</ref> | ||
Biochemistry of the enzyme: https://www.researchgate.net/profile/Elizabeth-Trimmer/publication/232764343_Methylenetetrahydrofolate_Reductase_Biochemical_Characterization_and_Medical_Significance/links/5541077d0cf232222731506c/Methylenetetrahydrofolate-Reductase-Biochemical-Characterization-and-Medical-Significance.pdf | Biochemistry of the enzyme: https://www.researchgate.net/profile/Elizabeth-Trimmer/publication/232764343_Methylenetetrahydrofolate_Reductase_Biochemical_Characterization_and_Medical_Significance/links/5541077d0cf232222731506c/Methylenetetrahydrofolate-Reductase-Biochemical-Characterization-and-Medical-Significance.pdf | ||
| + | ==Your Heading Here (maybe something like 'Structure')== | ||
| + | <StructureSection load='3rec' size='350' side='right' caption='Escherichia coli reca protein-bound DNA (PDB entry [[3rec]])' scene=''> | ||
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| + | Anything in this section will appear adjacent to the 3D structure and will be scrollable. <scene name='90/907477/Superposition/1'>Superposition</scene> | ||
| + | </StructureSection> | ||
Current revision
Textbook chapter on folate reactions: Chapter 17.5
Textbook on ping pong mechanisms: Libretext again
1ZP3, 1ZP4, 1ZPT, and 1ZRQ are the E. coli structures with substrate or product bound.
The paper is behind a paywall, but here is the link to the abstract: [1]
Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition[1]
Your Heading Here (maybe something like 'Structure')
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5 methyl folate as dietary supplement: [2]
Making the supplement: [3]
- ↑ Froese DS, Kopec J, Rembeza E, Bezerra GA, Oberholzer AE, Suormala T, Lutz S, Chalk R, Borkowska O, Baumgartner MR, Yue WW. Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition. Nat Commun. 2018 Jun 11;9(1):2261. doi: 10.1038/s41467-018-04735-2. PMID:29891918 doi:http://dx.doi.org/10.1038/s41467-018-04735-2
- ↑ Gilbody S, Lewis S, Lightfoot T. Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. Am J Epidemiol. 2007 Jan 1;165(1):1-13. doi: 10.1093/aje/kwj347. Epub 2006 Oct, 30. PMID:17074966 doi:http://dx.doi.org/10.1093/aje/kwj347
- ↑ Levin BL, Varga E. MTHFR: Addressing Genetic Counseling Dilemmas Using Evidence-Based Literature. J Genet Couns. 2016 Oct;25(5):901-11. doi: 10.1007/s10897-016-9956-7. Epub 2016, Apr 30. PMID:27130656 doi:http://dx.doi.org/10.1007/s10897-016-9956-7
