User:Olivia Gooch/Sandbox 1
From Proteopedia
< User:Olivia Gooch(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
=IgM B-cell Receptor= | =IgM B-cell Receptor= | ||
<StructureSection load='7xq8' size='350' frame='true' side='right' caption='IgM B-cell Receptor' scene=''> | <StructureSection load='7xq8' size='350' frame='true' side='right' caption='IgM B-cell Receptor' scene=''> | ||
| - | This is a default text for your page '''Olivia Gooch/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
==Structure== | ==Structure== | ||
| Line 12: | Line 10: | ||
== Relevance == | == Relevance == | ||
| + | The human IgM BCR has three domains: extracellular, transmembrane, and intracellular. The antigen binding site (located in the extracellular region) is specific to antigens, but the process is highly conserved across different BCRs. More specifically, the IgM BCR has a unique interaction concerning its Fc chains and a/b subunits. These interactions contribute to the overall structure of the protein. Within the a/b subunits themselves, there are several intermolecular interactions that cause the subunits to remain associated with each other. The following section explores these different domains and interactions in more detail. | ||
== Structural highlights == | == Structural highlights == | ||
| Line 18: | Line 17: | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| + | <ref name="Qiang">PMID:35981043</ref> | ||
<references/> | <references/> | ||
==Student Contributors== | ==Student Contributors== | ||
*Olivia Gooch | *Olivia Gooch | ||
Current revision
IgM B-cell Receptor
| |||||||||||
References
- ↑ Su Q, Chen M, Shi Y, Zhang X, Huang G, Huang B, Liu D, Liu Z, Shi Y. Cryo-EM structure of the human IgM B cell receptor. Science. 2022 Aug 19;377(6608):875-880. doi: 10.1126/science.abo3923. Epub 2022, Aug 18. PMID:35981043 doi:http://dx.doi.org/10.1126/science.abo3923
Student Contributors
- Olivia Gooch
