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4v7i
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4v7i]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12], [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3kc4 3kc4] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3kcr 3kcr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V7I FirstGlance]. <br> | <table><tr><td colspan='2'>[[4v7i]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12], [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3kc4 3kc4] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3kcr 3kcr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V7I FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v7i OCA], [https://pdbe.org/4v7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v7i RCSB], [https://www.ebi.ac.uk/pdbsum/4v7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v7i ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.6Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v7i OCA], [https://pdbe.org/4v7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v7i RCSB], [https://www.ebi.ac.uk/pdbsum/4v7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v7i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RL33_ECOLI RL33_ECOLI] | [https://www.uniprot.org/uniprot/RL33_ECOLI RL33_ECOLI] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | During protein synthesis, it is often necessary for the ribosome to form a complex with a membrane-bound channel, the SecY/Sec61 complex, in order to translocate nascent proteins across a cellular membrane. Structural data on the ribosome-channel complex are currently limited to low-resolution cryo-electron microscopy maps, including one showing a bacterial ribosome bound to a monomeric SecY complex. Using that map along with available atomic-level models of the ribosome and SecY, we have determined, through molecular dynamics flexible fitting (MDFF), an atomic-resolution model of the ribosome-channel complex. We characterized computationally the sites of ribosome-SecY interaction within the complex and determined the effect of ribosome binding on the SecY channel. We also constructed a model of a ribosome in complex with a SecY dimer by adding a second copy of SecY to the MDFF-derived model. The study involved 2.7-million-atom simulations over altogether nearly 50 ns. | ||
| - | |||
| - | Regulation of the protein-conducting channel by a bound ribosome.,Gumbart J, Trabuco LG, Schreiner E, Villa E, Schulten K Structure. 2009 Nov 11;17(11):1453-64. PMID:19913480<ref>PMID:19913480</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 4v7i" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Preprotein translocase|Preprotein translocase]] | + | *[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]] |
*[[Ribosomal protein S2|Ribosomal protein S2]] | *[[Ribosomal protein S2|Ribosomal protein S2]] | ||
*[[Ribosomal protein S21|Ribosomal protein S21]] | *[[Ribosomal protein S21|Ribosomal protein S21]] | ||
*[[Ribosome 3D structures|Ribosome 3D structures]] | *[[Ribosome 3D structures|Ribosome 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</SX> | </SX> | ||
Current revision
Ribosome-SecY complex.
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