8r5v
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8r5v is ON HOLD Authors: Dolot, R., Jastrzebska, K., Antonczyk, P. Description: Crystal structure of bovine pancreatic ribonuclease A in complex wi...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of bovine pancreatic ribonuclease A in complex with [Sp-PS]-mU-dT dinucleotide== | |
| + | <StructureSection load='8r5v' size='340' side='right'caption='[[8r5v]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8r5v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8R5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8R5V FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TF4:DICHLORO-ACETIC+ACID'>TF4</scene>, <scene name='pdbligand=Y4I:1-[(2~{R},4~{S},5~{R})-5-[[[(2~{R},6~{S})-2-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-6-(hydroxymethyl)morpholin-4-yl]-oxidanyl-phosphinothioyl]oxymethyl]-4-oxidanyl-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione'>Y4I</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8r5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8r5v OCA], [https://pdbe.org/8r5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8r5v RCSB], [https://www.ebi.ac.uk/pdbsum/8r5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8r5v ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Here, we present for the first time the synthesis of P-stereodefined morpholino phosphorothioate analogs by using a modified 1,3,2-oxathiaphospholane method (OTP method) and provide valuable structural insights into their stereochemistry. N-(2-Thio-4,4-pentamethylene-1,3,2-oxathiaphospholane) derivatives of morpholino-type nucleosides (mU-OTPs) were synthesized, separated into pure P-diastereomers and used to prepare P-stereodefined morpholino dinucleoside 3',5'-phosphorothioates. | ||
| - | + | P-Stereodefined morpholino dinucleoside 3',5'-phosphorothioates.,Jastrzebska K, Antonczyk P, Dolot R Org Biomol Chem. 2024 Oct 11. doi: 10.1039/d4ob01437e. PMID:39392463<ref>PMID:39392463</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8r5v" style="background-color:#fffaf0;"></div> |
| - | [[Category: Dolot | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Antonczyk P]] | ||
| + | [[Category: Dolot R]] | ||
| + | [[Category: Jastrzebska K]] | ||
Current revision
Crystal structure of bovine pancreatic ribonuclease A in complex with [Sp-PS]-mU-dT dinucleotide
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