8vjg
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8vjg is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human R14A Pin1 covalently bound to inhibitor 164A10== | |
| - | + | <StructureSection load='8vjg' size='340' side='right'caption='[[8vjg]], [[Resolution|resolution]] 1.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8vjg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VJG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ACH:(2~{S})-~{N}-[(2~{S})-1-azanyl-3-(5-fluoranyl-1~{H}-indol-3-yl)-1-oxidanylidene-propan-2-yl]-1-[[(3~{S})-2-ethanoyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-3-yl]carbonyl]piperidine-2-carboxamide'>A1ACH</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vjg OCA], [https://pdbe.org/8vjg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vjg RCSB], [https://www.ebi.ac.uk/pdbsum/8vjg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vjg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Blaha G]] | ||
| + | [[Category: Rodriguez I]] | ||
Current revision
Human R14A Pin1 covalently bound to inhibitor 164A10
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