8vxt
From Proteopedia
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(New page: '''Unreleased structure''' The entry 8vxt is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of mammalian Thorase filament, 3-layer refinement== | |
| - | + | <StructureSection load='8vxt' size='340' side='right'caption='[[8vxt]], [[Resolution|resolution]] 4.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8vxt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VXT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.25Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vxt OCA], [https://pdbe.org/8vxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vxt RCSB], [https://www.ebi.ac.uk/pdbsum/8vxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vxt ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ATAD1_MOUSE ATAD1_MOUSE] Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646).[UniProtKB:P28737][UniProtKB:Q8NBU5]<ref>PMID:21496646</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Dar MA]] | ||
| + | [[Category: Dawson TM]] | ||
| + | [[Category: Dawson VL]] | ||
| + | [[Category: Louder RK]] | ||
| + | [[Category: Umanah GK]] | ||
Current revision
Cryo-EM structure of mammalian Thorase filament, 3-layer refinement
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Categories: Large Structures | Mus musculus | Dar MA | Dawson TM | Dawson VL | Louder RK | Umanah GK
