8z94

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Current revision (10:24, 30 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8z94 is ON HOLD until Paper Publication
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==Cryo-EM structure of RIPK1 RHIM PFFs cross seeded RIPK3 RHIM amyloid fibril==
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<StructureSection load='8z94' size='340' side='right'caption='[[8z94]], [[Resolution|resolution]] 4.56&Aring;' scene=''>
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Authors: Ma, Y., Zhao, K., Liu, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8z94]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z94 FirstGlance]. <br>
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Description: Cryo-EM structure of RIPK1 RHIM PFFs cross seeded RIPK3 RHIM amyloid fibril
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.56&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z94 OCA], [https://pdbe.org/8z94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z94 RCSB], [https://www.ebi.ac.uk/pdbsum/8z94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z94 ProSAT]</span></td></tr>
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[[Category: Liu, C]]
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</table>
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[[Category: Ma, Y]]
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== Function ==
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[[Category: Zhao, K]]
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[https://www.uniprot.org/uniprot/RIPK3_HUMAN RIPK3_HUMAN] Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.<ref>PMID:19498109</ref> <ref>PMID:19524512</ref> <ref>PMID:19524513</ref> <ref>PMID:22265413</ref> <ref>PMID:22265414</ref> <ref>PMID:22421439</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Liu C]]
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[[Category: Ma Y]]
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[[Category: Zhao K]]

Current revision

Cryo-EM structure of RIPK1 RHIM PFFs cross seeded RIPK3 RHIM amyloid fibril

PDB ID 8z94

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