9c6g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Mcm double hexamer from human== | |
| - | + | <StructureSection load='9c6g' size='340' side='right'caption='[[9c6g]], [[Resolution|resolution]] 4.26Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9c6g]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9C6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9C6G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.26Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9c6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9c6g OCA], [https://pdbe.org/9c6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9c6g RCSB], [https://www.ebi.ac.uk/pdbsum/9c6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9c6g ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Liu | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/MCM4_HUMAN MCM4_HUMAN] Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency. The disease is caused by mutations affecting the gene represented in this entry. |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MCM4_HUMAN MCM4_HUMAN] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.<ref>PMID:16899510</ref> <ref>PMID:9305914</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lin Q]] | ||
| + | [[Category: Liu C]] | ||
| + | [[Category: Xu N]] | ||
Current revision
Mcm double hexamer from human
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Categories: Homo sapiens | Large Structures | Lin Q | Liu C | Xu N
