1x18

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[[Image:1x18.gif|left|200px]]
 
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==Contact sites of ERA GTPase on the THERMUS THERMOPHILUS 30S SUBUNIT==
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The line below this paragraph, containing "STRUCTURE_1x18", creates the "Structure Box" on the page.
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<SX load='1x18' size='340' side='right' viewer='molstar' caption='[[1x18]], [[Resolution|resolution]] 13.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1x18]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X18 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 13.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x18 OCA], [https://pdbe.org/1x18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x18 RCSB], [https://www.ebi.ac.uk/pdbsum/1x18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x18 ProSAT]</span></td></tr>
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{{STRUCTURE_1x18| PDB=1x18 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RS2_THET8 RS2_THET8] Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.[HAMAP-Rule:MF_00291_B]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x1/1x18_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x18 ConSurf].
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<div style="clear:both"></div>
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'''Contact sites of ERA GTPase on the THERMUS THERMOPHILUS 30S SUBUNIT'''
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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*[[Ribosomal protein S11|Ribosomal protein S11]]
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==Overview==
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*[[Ribosomal protein S18|Ribosomal protein S18]]
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Era (E. coliRas-like protein) is a highly conserved and essential GTPase in bacteria. It binds to the 16S ribosomal RNA (rRNA) of the small (30S) ribosomal subunit, and its depletion leads to accumulation of an unprocessed precursor of the 16S rRNA. We have obtained a three-dimensional cryo-electron microscopic map of the Thermus thermophilus 30S-Era complex. Era binds in the cleft between the head and platform of the 30S subunit and locks the subunit in a conformation that is not favorable for association with the large (50S) ribosomal subunit. The RNA binding KH motif present within the C-terminal domain of Era interacts with the conserved nucleotides in the 3' region of the 16S rRNA. Furthermore, Era makes contact with several assembly elements of the 30S subunit. These observations suggest a direct involvement of Era in the assembly and maturation of the 30S subunit.
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*[[Ribosomal protein S2|Ribosomal protein S2]]
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*[[Ribosomal protein S7|Ribosomal protein S7]]
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==About this Structure==
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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1X18 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X18 OCA].
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__TOC__
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</SX>
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==Reference==
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[[Category: Large Structures]]
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Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly., Sharma MR, Barat C, Wilson DN, Booth TM, Kawazoe M, Hori-Takemoto C, Shirouzu M, Yokoyama S, Fucini P, Agrawal RK, Mol Cell. 2005 Apr 29;18(3):319-29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15866174 15866174]
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[[Category: Escherichia coli]]
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[[Category: Protein complex]]
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[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Agrawal, R K.]]
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[[Category: Agrawal RK]]
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[[Category: Barat, C.]]
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[[Category: Barat C]]
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[[Category: Sharma, M R.]]
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[[Category: Sharma MR]]
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[[Category: Contact sites of era protein on the 30s ribosomal subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:23:54 2008''
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Current revision

Contact sites of ERA GTPase on the THERMUS THERMOPHILUS 30S SUBUNIT

1x18, resolution 13.50Å

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OCA

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