1bso

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(New page: 200px<br /><applet load="1bso" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bso, resolution 2.23&Aring;" /> '''12-BROMODODECANOIC A...)
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[[Image:1bso.gif|left|200px]]<br /><applet load="1bso" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bso, resolution 2.23&Aring;" />
 
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'''12-BROMODODECANOIC ACID BINDS INSIDE THE CALYX OF BOVINE BETA-LACTOGLOBULIN'''<br />
 
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==Overview==
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==12-BROMODODECANOIC ACID BINDS INSIDE THE CALYX OF BOVINE BETA-LACTOGLOBULIN==
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The X-ray structure of bovine beta-lactoglobulin with the ligand, 12-bromododecanoic acid as a model for fatty acids has been determined at, a resolution of 2.23 A in the trigonal lattice Z form. The ligand binds, inside the calyx, resolving a long-standing controversy as to where, fatty-acid like ligands bind. The carboxylate head group lies at the, surface of the molecule, and the lid to the calyx is open at the pH of, crystallization (pH 7.3), consistent with the conformation observed in, ligand-free bovine beta-lactoglobulin in lattice Z at pH 7.1 and pH 8.2.
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<StructureSection load='1bso' size='340' side='right'caption='[[1bso]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bso]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BSO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRC:12-BROMODODECANOIC+ACID'>BRC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bso OCA], [https://pdbe.org/1bso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bso RCSB], [https://www.ebi.ac.uk/pdbsum/1bso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bso ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bs/1bso_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bso ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1BSO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with BRC as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BSO OCA].
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*[[Beta-lactoglobulin 3D structures|Beta-lactoglobulin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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12-Bromododecanoic acid binds inside the calyx of bovine beta-lactoglobulin., Qin BY, Creamer LK, Baker EN, Jameson GB, FEBS Lett. 1998 Nov 6;438(3):272-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9827560 9827560]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baker, E.N.]]
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[[Category: Baker EN]]
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[[Category: Creamer, L.K.]]
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[[Category: Creamer LK]]
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[[Category: Jameson, G.B.]]
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[[Category: Jameson GB]]
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[[Category: Qin, B.Y.]]
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[[Category: Qin BY]]
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[[Category: BRC]]
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[[Category: beta-lactoglobulin]]
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[[Category: ligand binding]]
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[[Category: x-ray crystal structure]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:53:26 2007''
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Current revision

12-BROMODODECANOIC ACID BINDS INSIDE THE CALYX OF BOVINE BETA-LACTOGLOBULIN

PDB ID 1bso

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