2fm9

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[[Image:2fm9.png|left|200px]]
 
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==Structure of Salmonella SipA residues 48-264==
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The line below this paragraph, containing "STRUCTURE_2fm9", creates the "Structure Box" on the page.
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<StructureSection load='2fm9' size='340' side='right'caption='[[2fm9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2fm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FM9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fm9 OCA], [https://pdbe.org/2fm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fm9 RCSB], [https://www.ebi.ac.uk/pdbsum/2fm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fm9 ProSAT]</span></td></tr>
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{{STRUCTURE_2fm9| PDB=2fm9 | SCENE= }}
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</table>
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== Function ==
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===Structure of Salmonella SipA residues 48-264===
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[https://www.uniprot.org/uniprot/SIPA_SALTY SIPA_SALTY] Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization. In vitro, forms a complex with host cell protein T-plastin increasing actin bundling. It inhibits ADF/cofilin-directed depolymerization both by preventing binding of ADF and cofilin and by displacing them from F-actin. Also protects F-actin from gelsolin-directed severing and reanneals gelsolin-severed F-actin fragments.<ref>PMID:10092234</ref> <ref>PMID:14992720</ref>
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== References ==
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<references/>
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 16507363 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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{{ABSTRACT_PUBMED_16507363}}
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[[Category: Lilic M]]
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[[Category: Stebbins CE]]
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==About this Structure==
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[[Category: Vujanac M]]
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2FM9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM9 OCA].
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==Reference==
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A common structural motif in the binding of virulence factors to bacterial secretion chaperones., Lilic M, Vujanac M, Stebbins CE, Mol Cell. 2006 Mar 3;21(5):653-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16507363 16507363]
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[[Category: Salmonella typhimurium]]
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[[Category: Single protein]]
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[[Category: Lilic, M.]]
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[[Category: Stebbins, C E.]]
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[[Category: Vujanac, M.]]
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[[Category: Bacterial]]
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[[Category: Salmonella]]
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[[Category: Sipa]]
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[[Category: Type ii secretion]]
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[[Category: Virulence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:23:12 2008''
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Current revision

Structure of Salmonella SipA residues 48-264

PDB ID 2fm9

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OCA

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