1u6p

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{{Seed}}
 
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[[Image:1u6p.png|left|200px]]
 
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==NMR Structure of the MLV encapsidation signal bound to the Nucleocapsid protein==
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The line below this paragraph, containing "STRUCTURE_1u6p", creates the "Structure Box" on the page.
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<StructureSection load='1u6p' size='340' side='right'caption='[[1u6p]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u6p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U6P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AP7:N1-PROTONATED+ADENOSINE-5-MONOPHOSPHATE'>AP7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1u6p| PDB=1u6p | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u6p OCA], [https://pdbe.org/1u6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u6p RCSB], [https://www.ebi.ac.uk/pdbsum/1u6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u6p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAG_MLVMS GAG_MLVMS] Gag polyprotein plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag, or to Gag binding host factors. Interaction with HECT ubiquitin ligases probably link the viral protein to the host ESCRT pathway and facilitate release.<ref>PMID:19864377</ref> Matrix protein p15 targets Gag and gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex (By similarity).<ref>PMID:19864377</ref> Capsid protein p30 forms the spherical core of the virion that encapsulates the genomic RNA-nucleocapsid complex (By similarity).<ref>PMID:19864377</ref> Nucleocapsid protein p10 is involved in the packaging and encapsidation of two copies of the genome. Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome. This binding is dependent on genome dimerization.<ref>PMID:19864377</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u6/1u6p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u6p ConSurf].
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<div style="clear:both"></div>
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===NMR Structure of the MLV encapsidation signal bound to the Nucleocapsid protein===
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==See Also==
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*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_15457265}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 15457265 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_15457265}}
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[[Category: Large Structures]]
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==About this Structure==
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1U6P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U6P OCA].
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==Reference==
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Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus., D'Souza V, Summers MF, Nature. 2004 Sep 30;431(7008):586-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15457265 15457265]
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[[Category: Moloney murine leukemia virus]]
[[Category: Moloney murine leukemia virus]]
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[[Category: Single protein]]
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[[Category: D'Souza V]]
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[[Category: Souza, V D.]]
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[[Category: Summers MF]]
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[[Category: Summers, M F.]]
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[[Category: A-c mismatch]]
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[[Category: A-minor k-turn]]
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[[Category: Bulge]]
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[[Category: G-a mismatch]]
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[[Category: G-u mismatch]]
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[[Category: Mlv]]
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[[Category: Nc]]
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[[Category: Stem loop]]
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[[Category: U-u mismatch]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:21:37 2008''
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Current revision

NMR Structure of the MLV encapsidation signal bound to the Nucleocapsid protein

PDB ID 1u6p

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