1q5r

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{{Seed}}
 
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[[Image:1q5r.png|left|200px]]
 
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==The Rhodococcus 20S proteasome with unprocessed pro-peptides==
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The line below this paragraph, containing "STRUCTURE_1q5r", creates the "Structure Box" on the page.
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<StructureSection load='1q5r' size='340' side='right'caption='[[1q5r]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q5r]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q5R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q5r OCA], [https://pdbe.org/1q5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q5r RCSB], [https://www.ebi.ac.uk/pdbsum/1q5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q5r ProSAT]</span></td></tr>
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{{STRUCTURE_1q5r| PDB=1q5r | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSB1_RHOER PSB1_RHOER] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The R.erythropolis proteasomes are able to cleave oligopeptides after Tyr, Phe and Leu, very poorly after Arg but not after Glu. Thus, displays chymotrypsin-like activity, low trypsin-like activity but no caspase-like activity.[HAMAP-Rule:MF_02113]<ref>PMID:7583123</ref> <ref>PMID:9000518</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/1q5r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q5r ConSurf].
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<div style="clear:both"></div>
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===The Rhodococcus 20S proteasome with unprocessed pro-peptides===
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==See Also==
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_14659753}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 14659753 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_14659753}}
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==About this Structure==
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1Q5R is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5R OCA].
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==Reference==
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Crystal structures of the Rhodococcus proteasome with and without its pro-peptides: implications for the role of the pro-peptide in proteasome assembly., Kwon YD, Nagy I, Adams PD, Baumeister W, Jap BK, J Mol Biol. 2004 Jan 2;335(1):233-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14659753 14659753]
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Protein complex]]
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[[Category: Rhodococcus erythropolis]]
[[Category: Rhodococcus erythropolis]]
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[[Category: Adams, P D.]]
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[[Category: Adams PD]]
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[[Category: Baumeister, W.]]
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[[Category: Baumeister W]]
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[[Category: Jap, B K.]]
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[[Category: Jap BK]]
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[[Category: Kwon, Y D.]]
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[[Category: Kwon YD]]
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[[Category: Nagy, I.]]
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[[Category: Nagy I]]
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[[Category: Inter-subunit contact]]
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[[Category: Pro-peptide]]
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[[Category: Proteasome assembly]]
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[[Category: Rhodococcus erythropoli]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:03:44 2008''
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Current revision

The Rhodococcus 20S proteasome with unprocessed pro-peptides

PDB ID 1q5r

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