This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2r5v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:20, 21 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2r5v.png|left|200px]]
 
-
<!--
+
==Hydroxymandelate Synthase Crystal Structure==
-
The line below this paragraph, containing "STRUCTURE_2r5v", creates the "Structure Box" on the page.
+
<StructureSection load='2r5v' size='340' side='right'caption='[[2r5v]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2r5v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Amycolatopsis_orientalis Amycolatopsis orientalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5V FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=HHH:(2S)-HYDROXY(4-HYDROXYPHENYL)ETHANOIC+ACID'>HHH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
{{STRUCTURE_2r5v| PDB=2r5v | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5v OCA], [https://pdbe.org/2r5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5v RCSB], [https://www.ebi.ac.uk/pdbsum/2r5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5v ProSAT]</span></td></tr>
-
 
+
</table>
-
===Hydroxymandelate Synthase Crystal Structure===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/HMAS_AMYOR HMAS_AMYOR] Required to synthesize hydroxyphenylglycine, a recurring skeletal component of nonproteinogenic macrocyclic peptide antibiotics such as vancomycin. Catalyzes the conversion of p-hydroxyphenylpyruvate to p-hydroxymandelate. The decarboxylation and hydroxylation activities of HmaS show novel and distinct regioselectivity, compared to all other known p-hydroxyphenylpyruvate dioxygenases, by hydroxylating the benzylic position of the substrate instead of the phenyl ring.<ref>PMID:11137816</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_18215022}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 18215022 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5v_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_18215022}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
2R5V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Amycolatopsis_orientalis Amycolatopsis orientalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5V OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5v ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
Two roads diverged: the structure of hydroxymandelate synthase from Amycolatopsis orientalis in complex with 4-hydroxymandelate., Brownlee J, He P, Moran GR, Harrison DH, Biochemistry. 2008 Feb 19;47(7):2002-13. Epub 2008 Jan 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18215022 18215022]
+
<references/>
-
[[Category: 4-hydroxymandelate synthase]]
+
__TOC__
 +
</StructureSection>
[[Category: Amycolatopsis orientalis]]
[[Category: Amycolatopsis orientalis]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Brownlee, J M.]]
+
[[Category: Brownlee JM]]
-
[[Category: Harrison, D H.T.]]
+
[[Category: Harrison DHT]]
-
[[Category: He, P.]]
+
[[Category: He P]]
-
[[Category: Moran, G R.]]
+
[[Category: Moran GR]]
-
[[Category: Dioxygenase]]
+
-
[[Category: Non-heme iron]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Vancomycin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:34:13 2008''
+

Current revision

Hydroxymandelate Synthase Crystal Structure

PDB ID 2r5v

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2r5v"
Personal tools