This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3c92

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:33, 21 February 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3c92.jpg|left|200px]]
 
-
<!--
+
==Thermoplasma acidophilum 20S proteasome with a closed gate==
-
The line below this paragraph, containing "STRUCTURE_3c92", creates the "Structure Box" on the page.
+
<SX load='3c92' size='340' side='right' viewer='molstar' caption='[[3c92]], [[Resolution|resolution]] 6.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3c92]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C92 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.8&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c92 OCA], [https://pdbe.org/3c92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c92 RCSB], [https://www.ebi.ac.uk/pdbsum/3c92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c92 ProSAT]</span></td></tr>
-
{{STRUCTURE_3c92| PDB=3c92 | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PSA_THEAC PSA_THEAC] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin-like activities.<ref>PMID:8999862</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/3c92_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c92 ConSurf].
 +
<div style="clear:both"></div>
-
===Thermoplasma acidophilum 20S proteasome with a closed gate===
+
==See Also==
-
 
+
*[[Proteasome 3D structures|Proteasome 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_18471981}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 18471981 is the PubMed ID number.
+
</SX>
-
-->
+
[[Category: Large Structures]]
-
{{ABSTRACT_PUBMED_18471981}}
+
-
 
+
-
==About this Structure==
+
-
3C92 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C92 OCA].
+
-
 
+
-
==Reference==
+
-
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases., Rabl J, Smith DM, Yu Y, Chang SC, Goldberg AL, Cheng Y, Mol Cell. 2008 May 9;30(3):360-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18471981 18471981]
+
-
[[Category: Proteasome endopeptidase complex]]
+
-
[[Category: Protein complex]]
+
[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
-
[[Category: Chang, S C.]]
+
[[Category: Chang SC]]
-
[[Category: Cheng, Y.]]
+
[[Category: Cheng Y]]
-
[[Category: Goldberg, A L.]]
+
[[Category: Goldberg AL]]
-
[[Category: Rabl, J.]]
+
[[Category: Rabl J]]
-
[[Category: Smith, D M.]]
+
[[Category: Smith DM]]
-
[[Category: Yu, Y.]]
+
[[Category: Yu Y]]
-
[[Category: Cytoplasm]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Protease]]
+
-
[[Category: Proteasome]]
+
-
[[Category: Protein complex]]
+
-
[[Category: Threonine protease]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 6 12:57:59 2008''
+

Current revision

Thermoplasma acidophilum 20S proteasome with a closed gate

3c92, resolution 6.80Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3c92"
Personal tools