2jay

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{{Seed}}
 
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[[Image:2jay.png|left|200px]]
 
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==Proteasome beta subunit PrcB from Mycobacterium tuberculosis==
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The line below this paragraph, containing "STRUCTURE_2jay", creates the "Structure Box" on the page.
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<StructureSection load='2jay' size='340' side='right'caption='[[2jay]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jay]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jay OCA], [https://pdbe.org/2jay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jay RCSB], [https://www.ebi.ac.uk/pdbsum/2jay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jay ProSAT]</span></td></tr>
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{{STRUCTURE_2jay| PDB=2jay | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSB_MYCTU PSB_MYCTU] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues. Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins. One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice. The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated.<ref>PMID:16468985</ref> <ref>PMID:18059281</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jay_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jay ConSurf].
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<div style="clear:both"></div>
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===PROTEASOME BETA SUBUNIT PRCB FROM MYCOBACTERIUM TUBERCULOSIS===
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==See Also==
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*[[Proteasome 3D structures|Proteasome 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2JAY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAY OCA].
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__TOC__
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[[Category: Mycobacterium tuberculosis]]
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</StructureSection>
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[[Category: Proteasome endopeptidase complex]]
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[[Category: Large Structures]]
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[[Category: Bartunik, H D.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Oberschall, A.]]
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[[Category: Bartunik HD]]
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[[Category: Strizhov, N.]]
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[[Category: Oberschall A]]
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[[Category: Hydrolase]]
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[[Category: Strizhov N]]
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[[Category: Proteasome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:35:32 2009''
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Current revision

Proteasome beta subunit PrcB from Mycobacterium tuberculosis

PDB ID 2jay

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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