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1l8w

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{{Seed}}
 
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[[Image:1l8w.png|left|200px]]
 
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<!--
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==Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi==
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The line below this paragraph, containing "STRUCTURE_1l8w", creates the "Structure Box" on the page.
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<StructureSection load='1l8w' size='340' side='right'caption='[[1l8w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l8w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8W FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1l8w| PDB=1l8w | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8w OCA], [https://pdbe.org/1l8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8w RCSB], [https://www.ebi.ac.uk/pdbsum/1l8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8w ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi===
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== Function ==
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[https://www.uniprot.org/uniprot/O06878_BORBG O06878_BORBG] The Vlp and Vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time. Switching between these genes is a mechanism of host immune response evasion.[RuleBase:RU363105]
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11923306}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11923306 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8w_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11923306}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1L8W is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8W OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l8w ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:11923306</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Borrelia burgdorferi]]
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[[Category: Borreliella burgdorferi]]
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[[Category: Eicken, C.]]
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[[Category: Large Structures]]
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[[Category: Hardham, J M.]]
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[[Category: Eicken C]]
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[[Category: Klabunde, T.]]
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[[Category: Hardham JM]]
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[[Category: Lawrenz, M B.]]
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[[Category: Klabunde T]]
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[[Category: Norris, S J.]]
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[[Category: Lawrenz MB]]
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[[Category: Sacchettini, J C.]]
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[[Category: Norris SJ]]
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[[Category: Sharma, V.]]
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[[Category: Sacchettini JC]]
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[[Category: Variable surface protein]]
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[[Category: Sharma V]]
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[[Category: Vmp-like sequence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:51:14 2009''
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Current revision

Crystal Structure of Lyme Disease Variable Surface Antigen VlsE of Borrelia burgdorferi

PDB ID 1l8w

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