This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2vn8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:02, 9 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2vn8.png|left|200px]]
 
-
<!--
+
==Crystal structure of human Reticulon 4 interacting protein 1 in complex with NADPH==
-
The line below this paragraph, containing "STRUCTURE_2vn8", creates the "Structure Box" on the page.
+
<StructureSection load='2vn8' size='340' side='right'caption='[[2vn8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2vn8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VN8 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-
{{STRUCTURE_2vn8| PDB=2vn8 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vn8 OCA], [https://pdbe.org/2vn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vn8 ProSAT]</span></td></tr>
-
 
+
</table>
-
===CRYSTAL STRUCTURE OF HUMAN RETICULON 4 INTERACTING PROTEIN 1 IN COMPLEX WITH NADPH===
+
== Disease ==
-
 
+
[https://www.uniprot.org/uniprot/RT4I1_HUMAN RT4I1_HUMAN] Autosomal recessive isolated optic atrophy. The disease is caused by variants affecting the gene represented in this entry.
-
 
+
== Function ==
-
==About this Structure==
+
[https://www.uniprot.org/uniprot/RT4I1_HUMAN RT4I1_HUMAN] Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.[UniProtKB:Q924D0]
-
2VN8 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VN8 OCA].
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vn8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vn8 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Large Structures]]
-
[[Category: Bountra, C.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Delft, F Von.]]
+
[[Category: Bountra C]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards A]]
-
[[Category: Elkins, J.]]
+
[[Category: Elkins J]]
-
[[Category: Filippakopoulos, P.]]
+
[[Category: Filippakopoulos P]]
-
[[Category: Guo, K.]]
+
[[Category: Guo K]]
-
[[Category: Oppermann, U.]]
+
[[Category: Oppermann U]]
-
[[Category: Pike, A C.W.]]
+
[[Category: Pike ACW]]
-
[[Category: Roos, A K.]]
+
[[Category: Roos AK]]
-
[[Category: Ugochukwu, E.]]
+
[[Category: Ugochukwu E]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt J]]
-
[[Category: Alternative splicing]]
+
[[Category: Von Delft F]]
-
[[Category: Mitochondrion]]
+
-
[[Category: Receptor inhibitor]]
+
-
[[Category: Transit peptide]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 13:21:51 2009''
+

Current revision

Crystal structure of human Reticulon 4 interacting protein 1 in complex with NADPH

PDB ID 2vn8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vn8"
Personal tools