Fibrin
From Proteopedia
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| - | [[Image: | + | [[Image:1n73b.png|left|250px|thumb|Crystal Structure of Fibrin from ''Petromyzon marinus'', [[1n73]]]] |
{{STRUCTURE_1n73| PDB=1n73 | SIZE=300| SCENE=Fibrin/Cv/2 |right|CAPTION=Fibrin from ''Petromyzon marinus'', [[1n73]] }} | {{STRUCTURE_1n73| PDB=1n73 | SIZE=300| SCENE=Fibrin/Cv/2 |right|CAPTION=Fibrin from ''Petromyzon marinus'', [[1n73]] }} | ||
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| + | [[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. Fibrinogen (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). The images at the left and at the right correspond to one representative Fibrin, ''i.e.'' the crystal structure of Fibrin from ''Petromyzon marinus'' ([[1n73]]). | ||
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| + | {{TOC limit|limit=2}} | ||
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| + | == 3D Structures of Fibrin == | ||
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| + | [[3h32]] – hFIa peptide+ hFI α, β, γ chains – human<br /> | ||
| + | [[2q9i]], [[2z4e]] - hFIa B-knob+ hFI α, β, γ chains<br /> | ||
| + | [[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br /> | ||
| + | [[1n8e]] - hFIa α, β, γ chains <br /> | ||
| + | [[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br /> | ||
| + | [[1fzc]] – hDDFIa+peptide<br /> | ||
Revision as of 08:49, 16 September 2010
Image:1n73b.png
Crystal Structure of Fibrin from Petromyzon marinus, 1n73
Fibrin (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. Fibrinogen (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). The images at the left and at the right correspond to one representative Fibrin, i.e. the crystal structure of Fibrin from Petromyzon marinus (1n73).
Contents |
3D Structures of Fibrin
3h32 – hFIa peptide+ hFI α, β, γ chains – human
2q9i, 2z4e - hFIa B-knob+ hFI α, β, γ chains
2hlo, 1n86 - hFIa α, β, γ chains + peptide
1n8e - hFIa α, β, γ chains
1n73 - FIa α, β, γ chains + peptide – Sea lamprey
1fzc – hDDFIa+peptide
