User:Lori Wetmore/Sandbox 3
From Proteopedia
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Revision as of 00:38, 27 September 2010
Contents |
Chloride Channels
Chloride channels come in many varieties.
ClC Channels
The ClC family of chloride channels are present in many species. Mammals contain 9 different types of ClC channels[1]. The members of the CLC channel family can be divided into different groups by a number of different characteristics including intracellular localization, tissue [specificity?], and basic function [2].
| ClC Channels within Homo sapiens | |||
|---|---|---|---|
| Channel Name | Tissue | Location Within Cell | Basic Function |
| ClC-1 | Skeletal Muscle | Plasma Membrane Ion Channel | |
| ClC-2 | Plasma Membrane Ion Channel | ||
| ClC-3 | H+/Cl- Exchange Transporter | ||
| ClC-4 | H+/Cl- Exchange Transporte | ||
| ClC-5 | H+/Cl- Exchange Transporte | ||
| ClC-6 | |||
| ClC-7 | |||
| ClC-Ka | Plasma Membrane Ion Channel | ||
| ClC-Kb | Plasma Membrane Ion Channel | ||
The Structure of ClC Channels
Much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structure of E. coli. The basic structure of ClC channels is that of a "double barrel", in which two . Within ClC-0, the two
1ots
2h2p
1kpl
Other Notes and Things
RAINBOW TIME
When viewed in (where the N-terminus is gradually shaded into the C-terminus according to the scale below)
| N | C |
References
- ↑ Jentsch TJ, Stein V, Weinreich F, Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev. 2002 Apr;82(2):503-68. PMID:11917096 doi:10.1152/physrev.00029.2001
- ↑ Accardi A, Walden M, Nguitragool W, Jayaram H, Williams C, Miller C. Separate ion pathways in a Cl-/H+ exchanger. J Gen Physiol. 2005 Dec;126(6):563-70. PMID:16316975 doi:10.1085/jgp.200509417
