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User:Lori Wetmore/Sandbox 3

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==The Structure of ClC Channels==
==The Structure of ClC Channels==
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<applet load='1kpl' size='300' frame='true' align='left' caption='The ClC-0 channel from S. typhimurium' />
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<applet load='1kpl' size='325' frame='true' align='left' scene name='User:Lori_Wetmore/Sandbox_3/Clc_channel/1' target='0' />
No exact structural information exists for eukaryotic ClC channels, and therefore, much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structures of prokaryotes such as <i>E. coli</i>.
No exact structural information exists for eukaryotic ClC channels, and therefore, much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structures of prokaryotes such as <i>E. coli</i>.

Revision as of 04:01, 27 September 2010

Contents

Chloride Channels

Chloride channels come in many varieties.

ClC Channels

The ClC family of chloride channels are present in many species. Mammals contain 9 different types of ClC channels[1]. The members of the CLC channel family can be divided into different groups by a number of different characteristics including intracellular localization, tissue [specificity?], and basic function [2].


ClC Channels within Homo sapiens
Channel Name Tissue Location Within Cell Basic Function
ClC-1 Skeletal Muscle Plasma Membrane Ion Channel
ClC-2 Plasma Membrane Ion Channel
ClC-3 H+/Cl- Exchange Transporter
ClC-4 H+/Cl- Exchange Transporter
ClC-5 H+/Cl- Exchange Transporter
ClC-6
ClC-7
ClC-Ka Plasma Membrane Ion Channel
ClC-Kb Plasma Membrane Ion Channel


The Structure of ClC Channels

PDB ID 1kpl

Drag the structure with the mouse to rotate

No exact structural information exists for eukaryotic ClC channels, and therefore, much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structures of prokaryotes such as E. coli.

The ClC channel is composed of four distinct subunits, with each subunit consisting of 18 alpha helices. The basic structure of ClC channels is that of a , in which two single-pore monomers combine to form a double-pore channel [3]. Within ClC-0, the two . This double-barreled structure applies particularly to the ___ channels. Each of these pores is capable of transporting Cl- ions (light blue).



1ots 2h2p 1kpl




Other Notes and Things

RAINBOW TIME


When viewed in (where the N-terminus is gradually shaded into the C-terminus according to the scale below)

N               C

References

  1. ↑ Jentsch TJ, Stein V, Weinreich F, Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev. 2002 Apr;82(2):503-68. PMID:11917096 doi:10.1152/physrev.00029.2001
  2. ↑ Accardi A, Walden M, Nguitragool W, Jayaram H, Williams C, Miller C. Separate ion pathways in a Cl-/H+ exchanger. J Gen Physiol. 2005 Dec;126(6):563-70. PMID:16316975 doi:10.1085/jgp.200509417
  3. ↑ Jentsch TJ, Stein V, Weinreich F, Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev. 2002 Apr;82(2):503-68. PMID:11917096 doi:10.1152/physrev.00029.2001

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Lori Wetmore

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