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User:Lori Wetmore/Sandbox 3

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No exact structural information exists for eukaryotic ClC channels, and therefore, much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structures of prokaryotes such as <i>E. coli</i>.
No exact structural information exists for eukaryotic ClC channels, and therefore, much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structures of prokaryotes such as <i>E. coli</i>.
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The ClC channel is composed of four distinct subunits, with each subunit consisting of 18 alpha helices. The basic structure of ClC channels is that of a <scene name='User:Lori_Wetmore/Sandbox_3/Orange_top_double_barrel/2'>"double barrel"</scene>, in which two single-pore monomers combine to form a double-pore channel <ref>PMID:11917096</ref>. Within ClC-0, the two . This double-barreled structure applies particularly to the ___ channels. Each of these pores is capable of transporting Cl- ions (light blue).
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The ClC channel is composed of four subunits, with each subunit consisting of 18 alpha helices. The four subunits are organized into dimers, with one dimer located ____ and the other ____. There is an extensive interface between the two subunits forming the dimer. However, the interaction between the two dimers is not necessary for pore formation<ref>PMID:11796999</ref>.Instead, the basic structure of ClC channels is that of a <scene name='User:Lori_Wetmore/Sandbox_3/Orange_top_double_barrel/2'>"double barrel"</scene>, in which each of the subunits contains its own pore, and two subunit monomers combine to form a double-pore channel <ref>PMID:11917096</ref>. Within ClC-0, the two . This double-barreled structure applies particularly to the ___ channels. Each of these pores is capable of transporting Cl- ions (light blue).
<scene name='User:Lori_Wetmore/Sandbox_3/Orange_top/1'>Orange Top</scene>
<scene name='User:Lori_Wetmore/Sandbox_3/Orange_top/1'>Orange Top</scene>

Revision as of 20:02, 27 September 2010

Contents

Chloride Channels

Chloride channels come in many varieties.

ClC Channels

The ClC family of chloride channels are present in many species. Mammals contain 9 different types of ClC channels[1]. The members of the CLC channel family can be divided into different groups by a number of different characteristics including intracellular localization, tissue [specificity?], and basic function [2].


ClC Channels within Homo sapiens
Channel Name Tissue Location Within Cell Basic Function
ClC-1 Skeletal Muscle Plasma Membrane Ion Channel
ClC-2 Plasma Membrane Ion Channel
ClC-3 H+/Cl- Exchange Transporter
ClC-4 H+/Cl- Exchange Transporter
ClC-5 H+/Cl- Exchange Transporter
ClC-6
ClC-7
ClC-Ka Plasma Membrane Ion Channel
ClC-Kb Plasma Membrane Ion Channel


The Structure of ClC Channels

PDB ID 1kpl

Drag the structure with the mouse to rotate

No exact structural information exists for eukaryotic ClC channels, and therefore, much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structures of prokaryotes such as E. coli.

The ClC channel is composed of four subunits, with each subunit consisting of 18 alpha helices. The four subunits are organized into dimers, with one dimer located ____ and the other ____. There is an extensive interface between the two subunits forming the dimer. However, the interaction between the two dimers is not necessary for pore formation[3].Instead, the basic structure of ClC channels is that of a , in which each of the subunits contains its own pore, and two subunit monomers combine to form a double-pore channel [4]. Within ClC-0, the two . This double-barreled structure applies particularly to the ___ channels. Each of these pores is capable of transporting Cl- ions (light blue).



1ots 2h2p 1kpl




Other Notes and Things

RAINBOW TIME


When viewed in (where the N-terminus is gradually shaded into the C-terminus according to the scale below)

N               C

References

  1. ↑ Jentsch TJ, Stein V, Weinreich F, Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev. 2002 Apr;82(2):503-68. PMID:11917096 doi:10.1152/physrev.00029.2001
  2. ↑ Accardi A, Walden M, Nguitragool W, Jayaram H, Williams C, Miller C. Separate ion pathways in a Cl-/H+ exchanger. J Gen Physiol. 2005 Dec;126(6):563-70. PMID:16316975 doi:10.1085/jgp.200509417
  3. ↑ Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R. X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature. 2002 Jan 17;415(6869):287-94. PMID:11796999 doi:10.1038/415287a
  4. ↑ Jentsch TJ, Stein V, Weinreich F, Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev. 2002 Apr;82(2):503-68. PMID:11917096 doi:10.1152/physrev.00029.2001

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Lori Wetmore

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