User:Lori Wetmore/Sandbox 3
From Proteopedia
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The ClC channel is composed of four subunits, with each subunit consisting of 18 alpha helices. The four subunits are organized into dimers, with one dimer located ____ and the other ____. There is an extensive interface between the two subunits forming the dimer. However, the interaction between the two dimers is not necessary for pore formation<ref>PMID:11796999</ref>.Instead, the basic structure of ClC channels is that of a <scene name='User:Lori_Wetmore/Sandbox_3/Orange_top_double_barrel/2'>"double barrel"</scene>, in which each of the subunits contains its own pore, and two subunit monomers combine to form a double-pore channel <ref>PMID:11917096</ref>. Within ClC-0, the two . This double-barreled structure applies particularly to the ___ channels. Each of these pores is capable of transporting Cl- ions (light blue). | The ClC channel is composed of four subunits, with each subunit consisting of 18 alpha helices. The four subunits are organized into dimers, with one dimer located ____ and the other ____. There is an extensive interface between the two subunits forming the dimer. However, the interaction between the two dimers is not necessary for pore formation<ref>PMID:11796999</ref>.Instead, the basic structure of ClC channels is that of a <scene name='User:Lori_Wetmore/Sandbox_3/Orange_top_double_barrel/2'>"double barrel"</scene>, in which each of the subunits contains its own pore, and two subunit monomers combine to form a double-pore channel <ref>PMID:11917096</ref>. Within ClC-0, the two . This double-barreled structure applies particularly to the ___ channels. Each of these pores is capable of transporting Cl- ions (light blue). | ||
| - | <scene name='User:Lori_Wetmore/Sandbox_3/Orange_top/1'>Orange Top</scene> | + | <scene name='User:Lori_Wetmore/Sandbox_3/Orange_top/1'>Orange Top</scene><br> |
| - | <scene name='User:Lori_Wetmore/Sandbox_3/Try_to_highlight_glu_166/1'>EcClC Fab complex</scene> | + | <scene name='User:Lori_Wetmore/Sandbox_3/Try_to_highlight_glu_166/1'>EcClC Fab complex</scene><br> |
<scene name='User:Lori_Wetmore/Sandbox_3/Glu_166/1'>Glu 166</scene><br> | <scene name='User:Lori_Wetmore/Sandbox_3/Glu_166/1'>Glu 166</scene><br> | ||
| - | <scene name='User:Lori_Wetmore/Sandbox_3/Try_to_highlight_glu_166/2'>I messed up, but I want to see how it looks</scene> | + | <scene name='User:Lori_Wetmore/Sandbox_3/Try_to_highlight_glu_166/2'>I messed up, but I want to see how it looks</scene><br> |
| + | <scene name='User:Lori_Wetmore/Sandbox_3/Clc_channel/2'>Selectivity Filter Scen</scene> | ||
Revision as of 22:32, 27 September 2010
Contents |
Chloride Channels
Chloride channels come in many varieties.
ClC Channels
The ClC family of chloride channels are present in many species. Mammals contain 9 different types of ClC channels[1]. The members of the CLC channel family can be divided into different groups by a number of different characteristics including intracellular localization, tissue [specificity?], and basic function [2].
| ClC Channels within Homo sapiens | |||
|---|---|---|---|
| Channel Name | Tissue | Location Within Cell | Basic Function |
| ClC-1 | Skeletal Muscle | Plasma Membrane Ion Channel | |
| ClC-2 | Plasma Membrane Ion Channel | ||
| ClC-3 | H+/Cl- Exchange Transporter | ||
| ClC-4 | H+/Cl- Exchange Transporter | ||
| ClC-5 | H+/Cl- Exchange Transporter | ||
| ClC-6 | |||
| ClC-7 | |||
| ClC-Ka | Plasma Membrane Ion Channel | ||
| ClC-Kb | Plasma Membrane Ion Channel | ||
The Structure of ClC Channels
|
Though the basic types and functions of several ClC channels within eukaryotes have been elucidated, no exact structural information exists for eukaryotic ClC channels. Therefore, much of the current knowledge regarding ClC channel structure has come from the elucidation of the ClC structures of prokaryotes such as E. coli[3] and S. typhimurium[4].
The ClC channel is composed of four subunits, with each subunit consisting of 18 alpha helices. The four subunits are organized into dimers, with one dimer located ____ and the other ____. There is an extensive interface between the two subunits forming the dimer. However, the interaction between the two dimers is not necessary for pore formation[5].Instead, the basic structure of ClC channels is that of a , in which each of the subunits contains its own pore, and two subunit monomers combine to form a double-pore channel [6]. Within ClC-0, the two . This double-barreled structure applies particularly to the ___ channels. Each of these pores is capable of transporting Cl- ions (light blue).
1ots 2h2p 1kpl
Other Notes and Things
RAINBOW TIME
When viewed in (where the N-terminus is gradually shaded into the C-terminus according to the scale below)
| N | C |
References
- ↑ Jentsch TJ, Stein V, Weinreich F, Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev. 2002 Apr;82(2):503-68. PMID:11917096 doi:10.1152/physrev.00029.2001
- ↑ Accardi A, Walden M, Nguitragool W, Jayaram H, Williams C, Miller C. Separate ion pathways in a Cl-/H+ exchanger. J Gen Physiol. 2005 Dec;126(6):563-70. PMID:16316975 doi:10.1085/jgp.200509417
- ↑ Dutzler R, Campbell EB, MacKinnon R. Gating the selectivity filter in ClC chloride channels. Science. 2003 Apr 4;300(5616):108-12. Epub 2003 Mar 20. PMID:12649487 doi:10.1126/science.1082708
- ↑ Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R. X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature. 2002 Jan 17;415(6869):287-94. PMID:11796999 doi:10.1038/415287a
- ↑ Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R. X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature. 2002 Jan 17;415(6869):287-94. PMID:11796999 doi:10.1038/415287a
- ↑ Jentsch TJ, Stein V, Weinreich F, Zdebik AA. Molecular structure and physiological function of chloride channels. Physiol Rev. 2002 Apr;82(2):503-68. PMID:11917096 doi:10.1152/physrev.00029.2001
