User:Lori Wetmore/Sandbox 2
From Proteopedia
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==KcsA: A K+ channel== | ==KcsA: A K+ channel== | ||
| + | Potassium, a major cation in most cells, is responsible (in addition to other cations such as sodium) for the creation of the cell membrane potential, which is responsible for the generation of an action potential, which is necessary for a number of cellular functions such as neurotransmission, muscle contraction, and heart function. The proper balance of potassium in the cell is maintained by potassium ion pumps in the cellular membrane. To date, there are five potassium ion channels with a resolved structure (KcsA, KirBac1.1, KirBac3.1, KvAP, MthK), with KirBac3.1 being the most recently resolved, and they are all tetramers with several conserved secondary structural elements. | ||
==Channel Structure== | ==Channel Structure== | ||
Revision as of 20:22, 3 October 2010
Look for a family of channels (ion or otherwise) or transporters.
I'm going to discuss the family of potassium ion channels, and the specific channel I'll be using to illustrate will be the KcsA potassium ion channel. (http://www.rcsb.org/pdb/explore/explore.do?structureId=1k4c) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2383984/ http://www.ks.uiuc.edu/Research/smd_imd/kcsa/ http://jgp.rupress.org/content/128/5/569.long http://www.ncbi.nlm.nih.gov/pubmed/18621821 http://ion.ucdavis.edu/pdfs/bj02-KcsA.pdf http://ion.ucdavis.edu/pdfs/kchan1.pdf http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TFB-4HDGBRG-2&_user=10&_coverDate=03%2F01%2F2006&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d94a553308aa392e2459e882bb909dae&searchtype=a
Here are just a few of the things that I'll want to incorporate into my page at some point:
When viewed in (where the N-terminus is gradually shaded into the C-terminus according to the scale below)
| N | C |
|
Contents |
KcsA: A K+ channel
Potassium, a major cation in most cells, is responsible (in addition to other cations such as sodium) for the creation of the cell membrane potential, which is responsible for the generation of an action potential, which is necessary for a number of cellular functions such as neurotransmission, muscle contraction, and heart function. The proper balance of potassium in the cell is maintained by potassium ion pumps in the cellular membrane. To date, there are five potassium ion channels with a resolved structure (KcsA, KirBac1.1, KirBac3.1, KvAP, MthK), with KirBac3.1 being the most recently resolved, and they are all tetramers with several conserved secondary structural elements.
Channel Structure
Selecvitity Filter/s
Channel Function
Gating Mechanism
Ongoing Research
References
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.Zhou, Y., Morais-Cabral, J.H., Kaufman, A., MacKinnon, R. Journal: (2001) Nature 414: 43-48 PubMed: 11689936 View PubMed Abstract at NCBI DOI: 10.1038/35102009
