Pioglitazone
From Proteopedia
(Difference between revisions)
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| - | <applet load="" size="480" color="" frame="true" spin="on" Scene ="User:David_Canner/Sandbox_crestor/Rosu/1" align="right" caption="Rosuvastatin, also known as Crestor"/> | ||
===Better Known as: Actos=== | ===Better Known as: Actos=== | ||
* Marketed By: Takeda Pharmaceuticals<br /> | * Marketed By: Takeda Pharmaceuticals<br /> | ||
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* Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States. | * Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States. | ||
* The following is a list of Pharmacokinetic Parameters. See: [[Pharmaceutical Drugs]] for more information | * The following is a list of Pharmacokinetic Parameters. See: [[Pharmaceutical Drugs]] for more information | ||
| - | ===Mechanism of Action=== | ||
| - | |||
| - | ===Pharmacokinetics=== | ||
| - | |||
| - | {| class="wikitable" border="1" width="40%" style="text-align:center" | ||
| - | |- | ||
| - | ! colspan="6" align="center"| Glitazone Comparison | ||
| - | |- | ||
| - | ! Parameter | ||
| - | ! [[Pioglitazone]] (Actos) | ||
| - | ! [[Rosiglitazone]] (Avandia) | ||
| - | |||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr) | ||
| - | ! | ||
| - | ! | ||
| - | |||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Cmax|C<sub>max</sub>]] (ng/ml) | ||
| - | ! | ||
| - | ! | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Bioavailability_.28F.29|Bioavailability]] (%) | ||
| - | ! | ||
| - | ! | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Protein_Binding|Protein Binding]] (%) | ||
| - | ! 99 | ||
| - | ! 99 | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr) | ||
| - | ! 3-7 | ||
| - | ! 3-4 | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr) | ||
| - | ! | ||
| - | ! | ||
| - | |- | ||
| - | ! [[Pharmaceutical_Drugs#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM) | ||
| - | ! | ||
| - | ! | ||
| - | |- | ||
| - | ! Equivalent Dosage (mg) | ||
| - | ! | ||
| - | ! | ||
| - | |- | ||
| - | ! Metabolism | ||
| - | ! Hepatic <br/>(CYP2C8) | ||
| - | ! Hepatic <br/>(CYP2C8) | ||
| - | |} | ||
| - | |||
| - | ===Effectiveness and Side Effects=== | ||
| - | ====Effectiveness==== | ||
| - | |||
| - | ====Side Effects==== | ||
| - | |||
| - | ===Interesting Facts=== | ||
| - | |||
| - | ===The Jist=== | ||
===References=== | ===References=== | ||
Revision as of 08:50, 11 November 2010
Better Known as: Actos
- Marketed By: Takeda Pharmaceuticals
- Major Indication: Hypoglycemia & Type 2 Diabetes
- Drug Class: PPAR-γ Activator - Thiazolidinedione (Glitazones)
- Date of FDA Approval (Patent Expiration): 1999 (2011)
- 2009 Sales: $2.4 Billion [1]
- Why You Should Care: It is the best selling drug to treat Diabetes and is the 10th best selling drug in the United States.
- The following is a list of Pharmacokinetic Parameters. See: Pharmaceutical Drugs for more information
References
