Indinavir
From Proteopedia
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Revision as of 18:41, 1 December 2010
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Better Known as:
- Marketed By:
- Major Indication: Human Immunodeficiency Virus Infection
- Drug Class: HIV Protease Inhibitor
- Date of FDA Approval (Patent Expiration):
- 2006 Sales:
- Importance:
- The following is a list of Pharmacokinetic Parameters. See: Pharmaceutical Drugs for more information
Mechanism of Action
Pharmacokinetics
| HIV Protease Inhibitor Pharmacokinetics | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Ritonavir | Tipranavir | Indinavir | Saquinavir | Amprenavir | Foxamprenavir | Lopinavir | Ritonavir | Darunavir | Atazanavir | Nelfinavir |
| Tmax (hr) | Ritonavir | Tipranavir | Indinavir | Saquinavir | Amprenavir | Foxamprenavir | Lopinavir | Ritonavir | Darunavir | Atazanavir | Nelfinavir |
| Cmax (ng/ml) | Ritonavir | Tipranavir | Indinavir | Saquinavir | Amprenavir | Foxamprenavir | Lopinavir | Ritonavir | Darunavir | Atazanavir | Nelfinavir |
| Bioavailability (%) | Ritonavir | Tipranavir | Indinavir | Saquinavir | Amprenavir | Foxamprenavir | Lopinavir | Ritonavir | Darunavir | Atazanavir | Nelfinavir |
| Protein Binding (%) | Ritonavir | Tipranavir | Indinavir | Saquinavir | Amprenavir | Foxamprenavir | Lopinavir | Ritonavir | Darunavir | Atazanavir | Nelfinavir |
| T1/2 (hr) | Ritonavir | Tipranavir | Indinavir | Saquinavir | Amprenavir | Foxamprenavir | Lopinavir | Ritonavir | Darunavir | Atazanavir | Nelfinavir |
| AUC (ng/ml/hr) | Ritonavir | Tipranavir | Indinavir | Saquinavir | Amprenavir | Foxamprenavir | Lopinavir | Ritonavir | Darunavir | Atazanavir | Nelfinavir |
| IC50 (nM) | Ritonavir | Tipranavir | Indinavir | Saquinavir | Amprenavir | Foxamprenavir | Lopinavir | Ritonavir | Darunavir | Atazanavir | Nelfinavir |
| Dosage (mg) | Ritonavir | Tipranavir | Indinavir | Saquinavir | Amprenavir | Foxamprenavir | Lopinavir | Ritonavir | Darunavir | Atazanavir | Nelfinavir |
| Metabolism | Ritonavir | Tipranavir | Indinavir | Saquinavir | Amprenavir | Foxamprenavir | Lopinavir | Ritonavir | Darunavir | Atazanavir | Nelfinavir |
References
