Indinavir

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Line 21:		Line 21:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Foxamprenavir
	! Lopinavir		! Lopinavir
	! Ritonavir		! Ritonavir
Line 34:		Line 33:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Foxamprenavir
	! Lopinavir		! Lopinavir
	! Ritonavir		! Ritonavir
Line 47:		Line 45:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Foxamprenavir
	! Lopinavir		! Lopinavir
	! Ritonavir		! Ritonavir
Line 60:		Line 57:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Foxamprenavir
	! Lopinavir		! Lopinavir
	! Ritonavir		! Ritonavir
Line 73:		Line 69:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Foxamprenavir
	! Lopinavir		! Lopinavir
	! Ritonavir		! Ritonavir
Line 86:		Line 81:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Foxamprenavir
	! Lopinavir		! Lopinavir
	! Ritonavir		! Ritonavir
Line 99:		Line 93:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Foxamprenavir
	! Lopinavir		! Lopinavir
	! Ritonavir		! Ritonavir
Line 112:		Line 105:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Foxamprenavir
	! Lopinavir		! Lopinavir
	! Ritonavir		! Ritonavir
Line 125:		Line 117:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Foxamprenavir
	! Lopinavir		! Lopinavir
	! Ritonavir		! Ritonavir
Line 138:		Line 129:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Foxamprenavir
	! Lopinavir		! Lopinavir
	! Ritonavir		! Ritonavir

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Revision as of 18:51, 1 December 2010

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Better Known as:

• Marketed By:
  
• Major Indication: Human Immunodeficiency Virus Infection
  
• Drug Class: HIV Protease Inhibitor
• Date of FDA Approval (Patent Expiration):
  
• 2006 Sales:
• Importance:
• The following is a list of Pharmacokinetic Parameters. See: Pharmaceutical Drugs for more information

Mechanism of Action

Pharmacokinetics

HIV Protease Inhibitor Pharmacokinetics
Parameter	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Tmax (hr)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Cmax (ng/ml)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Bioavailability (%)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Protein Binding (%)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
T1/2 (hr)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
AUC (ng/ml/hr)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
IC50 (nM)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Dosage (mg)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Metabolism	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir

References