Indinavir

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Line 21:		Line 21:
	! [[Saquinavir]]		! [[Saquinavir]]
	! [[Amprenavir]]		! [[Amprenavir]]
-	! [[Lopinavir]]
	! [[Ritonavir]]		! [[Ritonavir]]
	! [[Darunavir]]		! [[Darunavir]]
Line 33:		Line 32:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 45:		Line 43:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 57:		Line 54:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 69:		Line 65:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 81:		Line 76:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 93:		Line 87:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 105:		Line 98:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 117:		Line 109:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 129:		Line 120:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
-	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir

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Revision as of 18:56, 1 December 2010

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Better Known as:

• Marketed By:
  
• Major Indication: Human Immunodeficiency Virus Infection
  
• Drug Class: HIV Protease Inhibitor
• Date of FDA Approval (Patent Expiration):
  
• 2006 Sales:
• Importance:
• The following is a list of Pharmacokinetic Parameters. See: Pharmaceutical Drugs for more information

Mechanism of Action

Pharmacokinetics

HIV Protease Inhibitor Pharmacokinetics
Parameter	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Tmax (hr)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Cmax (ng/ml)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Bioavailability (%)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Protein Binding (%)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
T1/2 (hr)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
AUC (ng/ml/hr)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
IC50 (nM)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Dosage (mg)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Metabolism	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir

References