Indinavir

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Line 16:		Line 16:
	|-		|-
	! Parameter		! Parameter
-	! [[Ritonavir]]	+	! Ritonavir
-	! [[Tipranavir]]	+	! Tipranavir
-	! [[Indinavir]]	+	! Indinavir
-	! [[Saquinavir]]	+	! Saquinavir
-	! [[Amprenavir]]	+	! Amprenavir
-	! [[Ritonavir]]	+	! Foxamprenavir
-	! [[Darunavir]]	+	! Lopinavir
-	! [[Atazanavir]]	+	! Ritonavir
-	! [[Nelfinavir]]	+	! Darunavir
		+	! Atazanavir
		+	! Nelfinavir
	|-		|-
	! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr)		! [[Pharmaceutical_Drugs#Tmax|T<sub>max</sub>]] (hr)
Line 32:		Line 34:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
		+	! Foxamprenavir
		+	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 43:		Line 47:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
		+	! Foxamprenavir
		+	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 54:		Line 60:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
		+	! Foxamprenavir
		+	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 65:		Line 73:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
		+	! Foxamprenavir
		+	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 76:		Line 86:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
		+	! Foxamprenavir
		+	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 87:		Line 99:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
		+	! Foxamprenavir
		+	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 98:		Line 112:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
		+	! Foxamprenavir
		+	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 109:		Line 125:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
		+	! Foxamprenavir
		+	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir
Line 120:		Line 138:
	! Saquinavir		! Saquinavir
	! Amprenavir		! Amprenavir
		+	! Foxamprenavir
		+	! Lopinavir
	! Ritonavir		! Ritonavir
	! Darunavir		! Darunavir

---

Revision as of 18:57, 1 December 2010

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Better Known as:

• Marketed By:
  
• Major Indication: Human Immunodeficiency Virus Infection
  
• Drug Class: HIV Protease Inhibitor
• Date of FDA Approval (Patent Expiration):
  
• 2006 Sales:
• Importance:
• The following is a list of Pharmacokinetic Parameters. See: Pharmaceutical Drugs for more information

Mechanism of Action

Pharmacokinetics

HIV Protease Inhibitor Pharmacokinetics
Parameter	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Foxamprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Tmax (hr)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Foxamprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Cmax (ng/ml)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Foxamprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Bioavailability (%)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Foxamprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Protein Binding (%)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Foxamprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
T1/2 (hr)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Foxamprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
AUC (ng/ml/hr)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Foxamprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
IC50 (nM)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Foxamprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Dosage (mg)	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Foxamprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir
Metabolism	Ritonavir	Tipranavir	Indinavir	Saquinavir	Amprenavir	Foxamprenavir	Lopinavir	Ritonavir	Darunavir	Atazanavir	Nelfinavir

References