HIV Protease Inhibitor Resistance Profile

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This page serves as a hub for visualizing the various mutations that confer resistance to [[Human Immunodeficiency Virus ]] against various. [[HIV Protease]] Inhibitors. To View FDA Approved Treatments for [[HIV]] See: [[Pharmaceutical_Drugs#Treatments|Treatments]]
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This page serves as a hub for visualizing the various mutations that confer resistance to [[Human Immunodeficiency Virus ]] against various. [[HIV Protease]] Inhibitors. Listed are various approved treatments and combinations for [[HIV]] (See: [[Pharmaceutical_Drugs#Treatments|Treatments]]) along with those mutations which typically confer resistance to the drug.
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Revision as of 12:04, 2 December 2010

This page serves as a hub for visualizing the various mutations that confer resistance to Human Immunodeficiency Virus against various. HIV Protease Inhibitors. Listed are various approved treatments and combinations for HIV (See: Treatments) along with those mutations which typically confer resistance to the drug.

Ligands, Cofactors and Coenzymes

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Resistance Mutations
Inhibitor/ Mutation Site L10 V11 I13 G16 K20 L24 D30 V32 L33 E34 E35 M36 K43 M46 I47 G48 I50 F53 I54 Q58 D60 I62 L63 I64 H69 A71 G73 T74 L76 V77 V82 N83 I84 I85 N88 L89 L90 I93
Ritonavir I,R,V - - - M,R - - I F - - I - I,L - - - - V,L - - - - - - V,T - - - I A,F,T, S - V - - - M -
Indinavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - - I A,F,T V - - - M -
Saquinavir I,R,V - - - - - - - - - - - - - - V - - V,L - - - - - - V,T S - - I A - V - - - M -
Nelfinavir F,I - - - - - N - - - - I - I,L - - - - - - - - - - - V,T - - - I A,F,T, S - V - D,S M -
Amprenavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - - - - - V - - - M -
Atazanavir I,F,V - - - R,M,I I - I I,F,V - - I,L,V - I - V L - L - - - - - - V C,S,T, A - - - A - V - S - M -
Lopinavir & Ritonavir F,I,R, V - - - M,R I - I F - - - - I,L V,A - V L V,L,A, M,T,S - - - P - - V,T S - V - A,F,T, S - V - - - M
Atazanavir & Ritonavir I,F,V, C - - E R,M,I, T,V I - I I,F,V Q - I,L,V - I,L - V V L,Y L,V,M, T,A - E V - L,M,V - V,I,T, L C,S,T, A - - - A,T,F, I - V V S - M L,M
Darunavir & Ritonavir - I - - - - - I F - - - - - V - V - M,L - - - - - - - - P V - - - V - - V - -
Fosamprenavir & Ritonavir F,I,R, V - - - - - - I - - - - - I,L V - V - L,V,M - - - - - - - S - V - A,F,S, T - V - - - M -
Indinavir & Ritonavir I,R,V - - - M,R I - I - - - I - I,L - - - - V - - - - - - V,T S,A - V I A,F,T - V - - - M -
Saquinavir & Ritonavir I,R,V - - - - I - - - - - - - - - V - - V,L - - V - - - V,T S - - I A,F,T, S - V - - - M -
Tipranavir & Ritonavir V - V - M,R - - - F - G I T L V - - - A,M,V E - - - - K - - P - - L,T D V - - - M -

References

Proteopedia Page Contributors and Editors (what is this?)

David Canner

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