Tositumomab

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Revision as of 06:38, 6 December 2010

Pharmacokinetics

Anti-CD20 Monoclonal Antibody Pharmacokinetics
Parameter	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
Tmax (hr)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
Cmax (ng/ml)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
Bioavailability (%)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
Protein Binding (%)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
T1/2 (hr)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
AUC (ng/ml/hr)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
Clearance (L/h)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
IC50 (nM)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
Dosage (mg)	Tositumomab	Ofatumumab	Rituximab	Ibritumomab
Metabolism	Tositumomab	Ofatumumab	Rituximab	Ibritumomab