Phospholipase A2

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{{STRUCTURE_1yxh| PDB=1yxh | SIZE=300| SCENE=Phospholipase_A2/Cv/1 |right|CAPTION=Phospholipase A2 from ''Naja naja sagittifera'' [[1yxh]] }}
{{STRUCTURE_1yxh| PDB=1yxh | SIZE=300| SCENE=Phospholipase_A2/Cv/1 |right|CAPTION=Phospholipase A2 from ''Naja naja sagittifera'' [[1yxh]] }}
-
[[Phospholipase A2]] (PLA2) is an enzyme which releases fatty acids from glycerol. It is found in mammals and in snake venoms. PLA2 releases arachidonic acid from membranes causing inflammation and pain. PLA2 from the snake Bothrops jararacussu is called bothropstoxin (BTX). The images at the left and at the right correspond to one representative PLA2, ''i.e.'' the crystal structure of Phospholipase A2 from ''Naja naja sagittifera'' ([[1yxh]]).
+
[[Phospholipase A2]] (PLA2) is an enzyme which releases fatty acids from glycerol. It is found in mammals and in snake venoms. PLA2 releases arachidonic acid from membranes causing inflammation and pain. PLA2 from the snake Bothrops jararacussu is called bothropstoxin (BTX) and from Bothrops pirajai – piratoxin (PTX) . The viperotoxin (VTX) is a heterodimer of very homologous PLA2 called RV-4/RV-7. The intracellular PLA2 – cystolic PLA2 (cPLA2) – are larger than the secreted PLA2 and contains the targeting C2 domain. The pro-phosphlipase (PPLA2) is a pancreatic PLA2 whose 7-mer N-terminal peptide is being cleaved off to produce the active PLA2. The PLA2 contains many isozymes which are ordered by groups and named accordingly, ie., group I is PLA2G1. The images at the left and at the right correspond to one representative PLA2, ''i.e.'' the crystal structure of Phospholipase A2 from ''Naja naja sagittifera'' ([[1yxh]]).
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=== PLA2 ===
=== PLA2 ===
-
 
+
[[1une]], [[1mkt]], [[1irb]], [[1bp2]], [[1bpq]], [[1g4i]], [[2bp2]], [[2bpp]] - bPLA2 – bovine<br />
 +
[[2zp3]], [[2zp4]], [[2zp5]], [[1c74]], [[1kvw]], [[1kvx]], [[1kvy]], [[1ceh]], [[1mks]], [[1mku]], [[1vkq]], [[1vl9]], [[2bax]], [[2bch]], [[2bd1]], [[1o3w]] – bPLA2 (mutant) – bovine<br />
 +
[[1bvm]] – bPLA2 - NMR<br />
[[1qll]], [[2q2j]] – PLA2 – ''Bothrops pirajai''<br />
[[1qll]], [[2q2j]] – PLA2 – ''Bothrops pirajai''<br />
-
[[2zp3]], [[2zp4]], [[2zp5]] – bPLA2 (mutant) – bovine<br />
 
[[2qog]] – PLA2 – ''Crotalus durissus''<br />
[[2qog]] – PLA2 – ''Crotalus durissus''<br />
[[2ph4]] – PLA2 – ''Zhaoermia mangshanensis''<br />
[[2ph4]] – PLA2 – ''Zhaoermia mangshanensis''<br />
[[2h4c]], [[1q6v]] – IvPLA2 – Indian viper<br />
[[2h4c]], [[1q6v]] – IvPLA2 – Indian viper<br />
 +
[[1vpi]] – PLA2 – sand viper<br />
[[2osn]], [[1fe5]], [[1dpy]] – kPLA2 – krait<br />
[[2osn]], [[1fe5]], [[1dpy]] – kPLA2 – krait<br />
[[1g0z]], [[1g2x]] – kPLA2 (mutant)<br />
[[1g0z]], [[1g2x]] – kPLA2 (mutant)<br />
[[2wg7]], [[2wg8]] – rPLA2 – rice<br />
[[2wg7]], [[2wg8]] – rPLA2 – rice<br />
-
[[1yxh]] – NsPLA2 – ''Naja sagittifera''<br />
+
[[1p2p]], [[4p2p]] – pPLA2 - pig<br />
-
[[1y6p]] – pPLA2 (mutant) – pig<br />
+
[[1y6p]], [[2phi]], [[3p2p]] – pPLA2 (mutant) – pig<br />
[[1sfv]], [[1sfw]], [[1pir]], [[1pis]] – pPLA2 - NMR<br />
[[1sfv]], [[1sfw]], [[1pir]], [[1pis]] – pPLA2 - NMR<br />
-
[[1oz6]] – PLA2 – ''Echis carinatus''<br />
+
[[1yxh]] – NsPLA2 – ''Naja sagittifera''<br />
 +
[[1oz6]], [[2qhe]] – PLA2 – ''Echis carinatus''<br />
[[1it4]], [[1it5]] – PLA2 – Stretomyces violaceoruber – NMR<br />
[[1it4]], [[1it5]] – PLA2 – Stretomyces violaceoruber – NMR<br />
[[1mg6]] – PLA2 – ''Agkistrodon acutus''<br />
[[1mg6]] – PLA2 – ''Agkistrodon acutus''<br />
 +
[[1s8g]], [[1s8h]], [[1s8i]] – PLA2 – copperhead<br />
 +
[[1ijl]] – PLA2 – ''Deinagkistrodon acutus''<br />
[[1mc2]] – PLA2 – Chinese moccasin<br />
[[1mc2]] – PLA2 – Chinese moccasin<br />
[[1c74]], [[1kvw]], [[1kvx]], [[1kvy]], [[1ceh]] – bPLA2 (mutant) – bovine<br />
[[1c74]], [[1kvw]], [[1kvx]], [[1kvy]], [[1ceh]] – bPLA2 (mutant) – bovine<br />
-
[[1une]], [[1mkt]], [[1irb]] - bPLA2<br />
+
[[1b4w]], [[1jia]], [[1c1j]] – AhPLA2 - ''Agkistrodon halys''<br />
-
[[1b4w]], [[1jia]] – AhPLA2 - ''Agkistrodon halys''<br />
+
[[1a2a]], [[1m8r]], [[1m8s]], [[1psj]] – PLA2 – ''Gloydius halys''<br />
-
[[1a3d]] – PLA2 – ''Naja naja''<br />
+
[[1a3d]], [[1a3f]], [[1ln8]], [[1mh2]], [[1mh8]], [[1ows]], [[1poa]], [[1psh]], [[1s6b]], [[1sz8]], [[1xxw]], [[1y75]], [[1yxl]], [[1yxh]] – PLA2 – ''Naja naja''<br />
-
[[1ae7]] – PLA2 – ''Notechis scutatus''<br />
+
[[2osh]] – PLA2 – Chinese cobra<br />
 +
[[1ae7]], [[2not]] – PLA2 – ''Notechis scutatus''<br />
 +
[[1aok]], [[1jlt]], [[1q5t]], [[1rgb]], [[3dih]], [[3g8g]], [[3g8h]] – PLA2 – Vipera ammodytes<br />
 +
[[2i0u]] – PLA2 – ''Vipera nikolskii''<br />
 +
[[1ayp]], [[1bbc]], [[1pod]] – hPLA2 – human<br />
 +
[[1rlw]] – hPLA2 CALB domain<br />
 +
[[1cl5]], [[1fb2]], [[1vip]], [[2pvt]], [[2pyc]] – DrPLA2 – ''Daboia russellii''<br />
 +
[[1faz]], [[1kp4]] – PLA2 – ''Streptomyces violaceruber''<br />
 +
[[1god]] – PLA2 – ''Cerrophidion godmani''<br />
 +
[[1gp7]], [[1m8t]] – PLA2 – ''Ophiophagus hanna''<br />
 +
[[1ozy]], [[1p7o]], [[1pwo]] – PLA2 – ''Micropechis ikahena''<br />
 +
[[1pp2]] – PLA2 – rattlesnake<br />
 +
[[1ppa]], [[1vap]] – PLA2 – cottonmouth<br />
 +
[[1u4j]] – PLA2 – ''Bungarus caeruleus''<br />
 +
[[2aoz]] – PLA2 – ''Atropoides nummifer''
 +
 
 +
===PLA2 group I===
 +
 
 +
[[3elo]] – hPLA2G1B<br />
 +
[[3fvi]], [[3fvj]] – pPLA2G1B+octyl sulfate<br />
 +
[[3l30]], [[3l69]] - pPLA2GI1+berberine derivative<br />
 +
[[3osh]] – NnPLA2G1+atropin
 +
 
 +
===PLA2 group II===
 +
 
 +
[[1j1a]] – hPLA2G2A<br />
 +
[[1n28]], [[1n29]] – hPLA2G2A (mutant)<br />
 +
[[1kqu]], [[1kvo]] – hPLA2G2A+substrate analog<br />
 +
[[3gf8]] – DrPLA2G2+polypeptide
 +
 
 +
===Human PLA2 group X===
 +
 
 +
[[1le6]], [[1le7]] – hPLA2G10
 +
 
 +
===Human PLA2 group XVI===
 +
 
 +
[[2kyt]] – hPLA2G14 N-terminal
=== PLA2+inhibitor ===
=== PLA2+inhibitor ===
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[[3o4m]], [[3hsw]] – PLA2+inhibitor <br />
[[3o4m]], [[3hsw]] – PLA2+inhibitor <br />
-
[[2azy]], [[2azz]], [[2b00]], [[2b01]] – pPLA2+cholate derivative<br />
+
[[2azy]], [[2azz]], [[2b00]], [[2b01]], [[2b03]], [[2b04]] – pPLA2+cholate derivative<br />
[[1y6o]], [[1fx9]], [[1fxf]] – pPLA2+MJ33<br />
[[1y6o]], [[1fx9]], [[1fxf]] – pPLA2+MJ33<br />
[[1l8s]] – pPLA2+LPC-ether<br />
[[1l8s]] – pPLA2+LPC-ether<br />
 +
[[5p2p]] – pPLA2+substrate analog<br />
[[3nju]] – PLA2 group I+4-methoxy-benzoic acid – Andaman cobra<br />
[[3nju]] – PLA2 group I+4-methoxy-benzoic acid – Andaman cobra<br />
[[2wq5]] – PLA2+minocyclin – Indian cobra<br />
[[2wq5]] – PLA2+minocyclin – Indian cobra<br />
 +
[[1oxl]] – IcPLA2+indole<br />
[[3h1x]], [[3fo7]] – IvPLA2+indomethacin <br />
[[3h1x]], [[3fo7]] – IvPLA2+indomethacin <br />
[[3fg5]] – IvPLA2+pentapeptide+ajmaline<br />
[[3fg5]] – IvPLA2+pentapeptide+ajmaline<br />
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[[1fdk]] – bPLA2+MJ33<br />
[[1fdk]] – bPLA2+MJ33<br />
[[1mkv]] – bPLA2+transition state analog<br />
[[1mkv]] – bPLA2+transition state analog<br />
-
 
+
[[1o2e]] – bPLA2 (mutant)+anisic acid<br />
 +
[[2b96]] - bPLA2+benzoic acid derivative<br />
 +
[[3bp2]] – bPLA2+pyruvic acid<br />
 +
[[1pob]] -NnPLA2+transition state analog<br />
 +
[[1poc]] - PLA2+transition state analog – Honey bee<br />
 +
[[1db4]], [[1db5]], [[1dcy]] – hPLA2+indole<br />
 +
[[1poe]] – hPLA2+phosphonyl inhibitor<br />
 +
[[1fv0]] – DrPLA2+aristolochic acid<br />
 +
[[1sv3]] - DrPLA2+benzoic acid derivative<br />
 +
[[1tp2]], [[2pws]], [[2q1p]] – DrPLA2+fatty acid<br />
 +
[[1sv9]], [[1sxk]], [[1zyx]], [[2b17]], [[2qvd]] – DrPLA2+anti-inflammatory agent<br />
 +
[[1kpm]] – DrPLA2+vitamin E<br />
 +
[[1oyf]] – DrPLA2+venom-6 methyl-heptanol<br />
 +
[[1q7a]] – DrPLA2+oxyphenabutazone<br />
 +
[[1y38]] – DrPLA2+glycerophosphate<br />
 +
[[1zr8]] – DrPLA2+ajmaline<br />
 +
[[2arm]] – DrPLA2+atropine<br />
 +
[[2dpz]] – DrPLA2 +hydroxyphenyl acetamide<br />
 +
[[2oli]], [[2oth]], [[2oyf]] – DrPLA2+indole derivative<br />
 +
[[2oub]] – DrPLA2+atenolol<br />
 +
[[2pmj]] – DrPLA2+benzopyrone<br />
 +
[[2zbh]] – DrPLA2+bavachalcone<br />
 +
[[1po8]], [[1tc8]] – kPLA2+fatty acid<br />
 +
[[1xxs]] – PLA2+fatty acid – ''Bothrops moojeni''<br />
 +
[[2qhd]] – EcPLA2+fatty acid<br />
 +
[[3bjw]] – EcPLA2+suramin<br />
 +
[[1y4l]] – PLA2+suramin – ''Bothrops asper''
=== PLA2+polypeptide ===
=== PLA2+polypeptide ===
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[[2o1n]], [[2d02]], [[2fnx]], [[1zm6]], [[1tdv]], [[1tg4]], [[1t37]] - IvPLA2+polypeptide<br />
[[2o1n]], [[2d02]], [[2fnx]], [[1zm6]], [[1tdv]], [[1tg4]], [[1t37]] - IvPLA2+polypeptide<br />
 +
[[1jq8]], [[1jq9]] - DsPLA2+polypeptide<br />
 +
[[1mf4]], [[2rd4]], [[3gci]], [[3jq5]], [[3jql]], [[3jti]] - NnPLA2+polypeptide<br />
 +
[[1skg]], [[1sqz]], [[1tg1]], [[1tj9]], [[1tjk]], [[1tk4]], [[2do2]], [[2g58]], [[2gns]], [[2pb8]] - DrPLA2+polypeptide
-
=== Bothropstoxin ===
+
=== Bothrops toxins ===
-
[[3i3h]], [[3i3i]], [[3hzd]], [[2oqd]], [[1zlb]], [[1umv]] – BTX<br />
+
[[3i3h]], [[3i3i]], [[3hzd]], [[2oqd]], [[1zlb]], [[1umv]], [[1u73]], [[1zl7]] – BTX<br />
[[3jr8]] – BTXD+Ca<br />
[[3jr8]] – BTXD+Ca<br />
[[3hzw]], [[3i03]] – BTX+BPB<br />
[[3hzw]], [[3i03]] – BTX+BPB<br />
[[3iq3]], [[2h8i]] – BTX + PEG<br />
[[3iq3]], [[2h8i]] – BTX + PEG<br />
 +
[[1z76]] – BTX+bromophenacyl<br />
 +
[[1gmz]], [[1qll]], [[2q2j]], [[2ok9]] - PTX<br />
 +
[[3cyl]] – PTX+α-tocopherol
 +
 +
===Viperotoxin===
 +
 +
[[1oqs]] – DrRV4/RV7
 +
 +
===cPLA2===
 +
 +
[[1bci]] – h-cPLA2 C2 domain
 +
 +
===Pro-PLA2===
 +
 +
[[1hn4]] – pPPLA2+MJ33<br />
 +
[[4bp2]] – bPPLA2
 +
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:17, 27 December 2010

Image:1yxh.png
Crystal Structure of Phospholipase A2 from Naja naja sagittifera 1yxh

Template:STRUCTURE 1yxh

Phospholipase A2 (PLA2) is an enzyme which releases fatty acids from glycerol. It is found in mammals and in snake venoms. PLA2 releases arachidonic acid from membranes causing inflammation and pain. PLA2 from the snake Bothrops jararacussu is called bothropstoxin (BTX) and from Bothrops pirajai – piratoxin (PTX) . The viperotoxin (VTX) is a heterodimer of very homologous PLA2 called RV-4/RV-7. The intracellular PLA2 – cystolic PLA2 (cPLA2) – are larger than the secreted PLA2 and contains the targeting C2 domain. The pro-phosphlipase (PPLA2) is a pancreatic PLA2 whose 7-mer N-terminal peptide is being cleaved off to produce the active PLA2. The PLA2 contains many isozymes which are ordered by groups and named accordingly, ie., group I is PLA2G1. The images at the left and at the right correspond to one representative PLA2, i.e. the crystal structure of Phospholipase A2 from Naja naja sagittifera (1yxh).

Contents

3D Structures of Phospholipase A2

PLA2

1une, 1mkt, 1irb, 1bp2, 1bpq, 1g4i, 2bp2, 2bpp - bPLA2 – bovine
2zp3, 2zp4, 2zp5, 1c74, 1kvw, 1kvx, 1kvy, 1ceh, 1mks, 1mku, 1vkq, 1vl9, 2bax, 2bch, 2bd1, 1o3w – bPLA2 (mutant) – bovine
1bvm – bPLA2 - NMR
1qll, 2q2j – PLA2 – Bothrops pirajai
2qog – PLA2 – Crotalus durissus
2ph4 – PLA2 – Zhaoermia mangshanensis
2h4c, 1q6v – IvPLA2 – Indian viper
1vpi – PLA2 – sand viper
2osn, 1fe5, 1dpy – kPLA2 – krait
1g0z, 1g2x – kPLA2 (mutant)
2wg7, 2wg8 – rPLA2 – rice
1p2p, 4p2p – pPLA2 - pig
1y6p, 2phi, 3p2p – pPLA2 (mutant) – pig
1sfv, 1sfw, 1pir, 1pis – pPLA2 - NMR
1yxh – NsPLA2 – Naja sagittifera
1oz6, 2qhe – PLA2 – Echis carinatus
1it4, 1it5 – PLA2 – Stretomyces violaceoruber – NMR
1mg6 – PLA2 – Agkistrodon acutus
1s8g, 1s8h, 1s8i – PLA2 – copperhead
1ijl – PLA2 – Deinagkistrodon acutus
1mc2 – PLA2 – Chinese moccasin
1c74, 1kvw, 1kvx, 1kvy, 1ceh – bPLA2 (mutant) – bovine
1b4w, 1jia, 1c1j – AhPLA2 - Agkistrodon halys
1a2a, 1m8r, 1m8s, 1psj – PLA2 – Gloydius halys
1a3d, 1a3f, 1ln8, 1mh2, 1mh8, 1ows, 1poa, 1psh, 1s6b, 1sz8, 1xxw, 1y75, 1yxl, 1yxh – PLA2 – Naja naja
2osh – PLA2 – Chinese cobra
1ae7, 2not – PLA2 – Notechis scutatus
1aok, 1jlt, 1q5t, 1rgb, 3dih, 3g8g, 3g8h – PLA2 – Vipera ammodytes
2i0u – PLA2 – Vipera nikolskii
1ayp, 1bbc, 1pod – hPLA2 – human
1rlw – hPLA2 CALB domain
1cl5, 1fb2, 1vip, 2pvt, 2pyc – DrPLA2 – Daboia russellii
1faz, 1kp4 – PLA2 – Streptomyces violaceruber
1god – PLA2 – Cerrophidion godmani
1gp7, 1m8t – PLA2 – Ophiophagus hanna
1ozy, 1p7o, 1pwo – PLA2 – Micropechis ikahena
1pp2 – PLA2 – rattlesnake
1ppa, 1vap – PLA2 – cottonmouth
1u4j – PLA2 – Bungarus caeruleus
2aoz – PLA2 – Atropoides nummifer

PLA2 group I

3elo – hPLA2G1B
3fvi, 3fvj – pPLA2G1B+octyl sulfate
3l30, 3l69 - pPLA2GI1+berberine derivative
3osh – NnPLA2G1+atropin

PLA2 group II

1j1a – hPLA2G2A
1n28, 1n29 – hPLA2G2A (mutant)
1kqu, 1kvo – hPLA2G2A+substrate analog
3gf8 – DrPLA2G2+polypeptide

Human PLA2 group X

1le6, 1le7 – hPLA2G10

Human PLA2 group XVI

2kyt – hPLA2G14 N-terminal

PLA2+inhibitor

3o4m, 3hsw – PLA2+inhibitor
2azy, 2azz, 2b00, 2b01, 2b03, 2b04 – pPLA2+cholate derivative
1y6o, 1fx9, 1fxf – pPLA2+MJ33
1l8s – pPLA2+LPC-ether
5p2p – pPLA2+substrate analog
3nju – PLA2 group I+4-methoxy-benzoic acid – Andaman cobra
2wq5 – PLA2+minocyclin – Indian cobra
1oxl – IcPLA2+indole
3h1x, 3fo7 – IvPLA2+indomethacin
3fg5 – IvPLA2+pentapeptide+ajmaline
3cbi – IvPLA2+anisic acid+ajmaline
2qu9 – IvPLA2+eugenol
2otf – IvPLA2+atenolol
1zwp - IvPLA2+nimesulide
1th6 - IvPLA2+atropine
1td7 - IvPLA2+niflumic acid
1tgm - IvPLA2+aspirin
2wg9 – rPLA2+octanoic acid
1oxr – NsPLA2+aspirin
1bk9 – AhPLA2+PBPB
1fdk – bPLA2+MJ33
1mkv – bPLA2+transition state analog
1o2e – bPLA2 (mutant)+anisic acid
2b96 - bPLA2+benzoic acid derivative
3bp2 – bPLA2+pyruvic acid
1pob -NnPLA2+transition state analog
1poc - PLA2+transition state analog – Honey bee
1db4, 1db5, 1dcy – hPLA2+indole
1poe – hPLA2+phosphonyl inhibitor
1fv0 – DrPLA2+aristolochic acid
1sv3 - DrPLA2+benzoic acid derivative
1tp2, 2pws, 2q1p – DrPLA2+fatty acid
1sv9, 1sxk, 1zyx, 2b17, 2qvd – DrPLA2+anti-inflammatory agent
1kpm – DrPLA2+vitamin E
1oyf – DrPLA2+venom-6 methyl-heptanol
1q7a – DrPLA2+oxyphenabutazone
1y38 – DrPLA2+glycerophosphate
1zr8 – DrPLA2+ajmaline
2arm – DrPLA2+atropine
2dpz – DrPLA2 +hydroxyphenyl acetamide
2oli, 2oth, 2oyf – DrPLA2+indole derivative
2oub – DrPLA2+atenolol
2pmj – DrPLA2+benzopyrone
2zbh – DrPLA2+bavachalcone
1po8, 1tc8 – kPLA2+fatty acid
1xxs – PLA2+fatty acid – Bothrops moojeni
2qhd – EcPLA2+fatty acid
3bjw – EcPLA2+suramin
1y4l – PLA2+suramin – Bothrops asper

PLA2+polypeptide

2o1n, 2d02, 2fnx, 1zm6, 1tdv, 1tg4, 1t37 - IvPLA2+polypeptide
1jq8, 1jq9 - DsPLA2+polypeptide
1mf4, 2rd4, 3gci, 3jq5, 3jql, 3jti - NnPLA2+polypeptide
1skg, 1sqz, 1tg1, 1tj9, 1tjk, 1tk4, 2do2, 2g58, 2gns, 2pb8 - DrPLA2+polypeptide


Bothrops toxins

3i3h, 3i3i, 3hzd, 2oqd, 1zlb, 1umv, 1u73, 1zl7 – BTX
3jr8 – BTXD+Ca
3hzw, 3i03 – BTX+BPB
3iq3, 2h8i – BTX + PEG
1z76 – BTX+bromophenacyl
1gmz, 1qll, 2q2j, 2ok9 - PTX
3cyl – PTX+α-tocopherol

Viperotoxin

1oqs – DrRV4/RV7

cPLA2

1bci – h-cPLA2 C2 domain

Pro-PLA2

1hn4 – pPPLA2+MJ33
4bp2 – bPPLA2

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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