1qzf
From Proteopedia
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[[Image:1qzf.png|left|200px]] | [[Image:1qzf.png|left|200px]] | ||
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{{STRUCTURE_1qzf| PDB=1qzf | SCENE= }} | {{STRUCTURE_1qzf| PDB=1qzf | SCENE= }} | ||
===Crystal structure of DHFR-TS from Cryptosporidium hominis=== | ===Crystal structure of DHFR-TS from Cryptosporidium hominis=== | ||
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{{ABSTRACT_PUBMED_14555647}} | {{ABSTRACT_PUBMED_14555647}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[1qzf]] is a 5 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_hominis Cryptosporidium hominis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZF OCA]. | + | [[1qzf]] is a 5 chain structure of [[Dihydrofolate reductase]] and [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_hominis Cryptosporidium hominis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZF OCA]. |
==See Also== | ==See Also== | ||
| - | *[[Dihydrofolate reductase]] | + | *[[Dihydrofolate reductase|Dihydrofolate reductase]] |
| + | *[[Thymidylate synthase|Thymidylate synthase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:014555647</ref><ref group="xtra">PMID:016511011</ref><references group="xtra"/> |
[[Category: Cryptosporidium hominis]] | [[Category: Cryptosporidium hominis]] | ||
[[Category: Anderson, A C.]] | [[Category: Anderson, A C.]] | ||
Revision as of 08:29, 26 July 2012
Contents |
Crystal structure of DHFR-TS from Cryptosporidium hominis
Template:ABSTRACT PUBMED 14555647
About this Structure
1qzf is a 5 chain structure of Dihydrofolate reductase and Thymidylate synthase with sequence from Cryptosporidium hominis. Full crystallographic information is available from OCA.
See Also
Reference
- O'Neil RH, Lilien RH, Donald BR, Stroud RM, Anderson AC. Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase. J Biol Chem. 2003 Dec 26;278(52):52980-7. Epub 2003 Oct 9. PMID:14555647 doi:10.1074/jbc.M310328200
- Anderson AC. Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):258-62. Epub 2005 Feb 8. PMID:16511011 doi:10.1107/S1744309105002435
