2p4t
From Proteopedia
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Contents |
Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode
Template:ABSTRACT PUBMED 17473013
About this Structure
2p4t is a 1 chain structure of Dihydrofolate reductase with sequence from Escherichia coli. Full crystallographic information is available from OCA.
See Also
Reference
- Divya N, Grifith E, Narayana N. Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode. Protein Sci. 2007 Jun;16(6):1063-8. Epub 2007 May 1. PMID:17473013 doi:ps.062740907
- Narayana N. High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water molecules in the D2-symmetric active site. Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):695-706. Epub 2006, Jun 20. PMID:16790925 doi:S0907444906014764
- Narayana N, Matthews DA, Howell EE, Nguyen-huu X. A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site. Nat Struct Biol. 1995 Nov;2(11):1018-25. PMID:7583655
- Park H, Bradrick TD, Howell EE. A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition. Protein Eng. 1997 Dec;10(12):1415-24. PMID:9543003 doi:10.1093/protein/10.12.1415
