This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sandbox Reserved 162
From Proteopedia
| Line 1: | Line 1: | ||
<Structure load='1IL6' size='400' frame='true' align='right' caption='Human Interleukin-6, NMR, Minimized Average Structure' scene='Insert optional scene name here' /><!-- PLEASE DO NOT DELETE THIS TEMPLATE --> | <Structure load='1IL6' size='400' frame='true' align='right' caption='Human Interleukin-6, NMR, Minimized Average Structure' scene='Insert optional scene name here' /><!-- PLEASE DO NOT DELETE THIS TEMPLATE --> | ||
| - | [[Image:1il6.png | | + | [[Image:1il6.png | 200 px|left]] |
__TOC__ | __TOC__ | ||
== Background == | == Background == | ||
| Line 12: | Line 12: | ||
== IL-6 Receptor == | == IL-6 Receptor == | ||
| + | <Structure load='1N26' size='400' frame='true' align='right' caption='Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain ' scene='Insert optional scene name here' />[[Image:1n26.png|200 px|left]] | ||
== Clinical Applications == | == Clinical Applications == | ||
Revision as of 15:42, 26 March 2011
|
Contents |
Background
Human Interleukin-6 (IL-6) is a immune protein often categorized under hematopoietins. Since its discoverey, it has been known by many names including: interferon-ß2 (IFN-ß2), 26-kD protein, B-cell stimulatory factor-2 (BSF-2), hepatocyte stimulating factor (HSF), cytotoxic T-cell differentiation factor (CDF), interleukin-HP1 (IL-HP1), monocyte-granulocyte inducer type 2 (MGI-2), and hybridoma/plasmacytoma growth factor (HPGF/HGF). It wasn't until December of 1988 that is was givin the final moniker of IL-6 (PDB: 1IL6).
Structure
IL-6 is a monomer of 185 amino acids produced from T-Cells, macrophages, and endothelial cells found on a single gene at locus 7p21. It contains five alpha-helices and four of these helices constitute a classical four-helix bundle with the fifth helix located in the CD loop.
Functions
IL-6 Receptor
|
