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Chaperonin
From Proteopedia
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== 3D Structures of Chaperonin == | == 3D Structures of Chaperonin == | ||
| + | |||
| + | ''Update June 2011'' | ||
===Group I=== | ===Group I=== | ||
| - | + | ''Large subunit'' | |
[[3m6c]] – MtGroEL1 apical domain – ''Mycobacterium tuberculosis''<BR /> | [[3m6c]] – MtGroEL1 apical domain – ''Mycobacterium tuberculosis''<BR /> | ||
[[1sjp]] – MtGroEL2 residues 42-539<BR /> | [[1sjp]] – MtGroEL2 residues 42-539<BR /> | ||
| - | [[3fbh]], [[2eu1]], [[1j4z]], [[1kpo]], [[1oel]], [[1grl]] – EcGroEL (mutant) - ''Escherichia coli''<BR /> | + | [[3fbh]], [[2eu1]], [[1j4z]], [[1kpo]], [[1oel]], [[1grl]], [[2yey]] – EcGroEL (mutant) - ''Escherichia coli''<BR /> |
[[3e76]], [[2nwc]], [[1xck]], [[1ss8]] – EcGroEL<BR /> | [[3e76]], [[2nwc]], [[1xck]], [[1ss8]] – EcGroEL<BR /> | ||
[[3c9v]], [[3cau]] – EcGroEL – Cryo EM<BR /> | [[3c9v]], [[3cau]] – EcGroEL – Cryo EM<BR /> | ||
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[[1iok]] – CPN60 – ''Paracoccus denitrificans'' | [[1iok]] – CPN60 – ''Paracoccus denitrificans'' | ||
| - | + | ''Small subunit'' | |
[[3nx6]] – GroES residues 40-134 (mutant) – ''Xanthomonas oryzae''<BR /> | [[3nx6]] – GroES residues 40-134 (mutant) – ''Xanthomonas oryzae''<BR /> | ||
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[[1p3h]], [[1hx5]] – MtCPN10<BR /> | [[1p3h]], [[1hx5]] – MtCPN10<BR /> | ||
[[1p82]], [[1p83]] - MtCPN10 residues 1-25 - NMR<BR /> | [[1p82]], [[1p83]] - MtCPN10 residues 1-25 - NMR<BR /> | ||
| + | [[1egs]] - GroES residues 19-27 - NMR | ||
| - | + | ''Large + small subunit'' | |
[[1svt]], [[1pcq]] - EcGroEL + GroES<BR /> | [[1svt]], [[1pcq]] - EcGroEL + GroES<BR /> | ||
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[[1q3s]] - TkCPN α subunit (mutant) + ADP | [[1q3s]] - TkCPN α subunit (mutant) + ADP | ||
| - | + | ''CCT'' | |
[[2xsm]] – bCPN CCT – bovine<BR /> | [[2xsm]] – bCPN CCT – bovine<BR /> | ||
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[[1gml]], [[1gn1]] - CPN CCT γ subunit apical domain – mouse | [[1gml]], [[1gn1]] - CPN CCT γ subunit apical domain – mouse | ||
| - | + | ''Hsp33'' | |
[[3m7m]], [[1hw7]] – EcCPN Hsp33 N-terminal<BR /> | [[3m7m]], [[1hw7]] – EcCPN Hsp33 N-terminal<BR /> | ||
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[[1vzy]] - CPN Hsp33 (mutant) – ''Bacillus subtilis'' | [[1vzy]] - CPN Hsp33 (mutant) – ''Bacillus subtilis'' | ||
| - | + | ''Thermosome'' | |
[[1a6d]] - TaTherm α+β subunits – ''Thermoplasma acidophilum''<BR /> | [[1a6d]] - TaTherm α+β subunits – ''Thermoplasma acidophilum''<BR /> | ||
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[[3ko1]] – Therm – ''Acidianus tengchongensis'' | [[3ko1]] – Therm – ''Acidianus tengchongensis'' | ||
| + | [[1lep]] – CPN-10 – ''Mycobacterium leprae'' | ||
Revision as of 07:10, 13 June 2011
Chaperonin (CPN) are oligomeric proteins which mediate the folding of polypeptide chains. Group I CPNs are found in bacteria, chloroplasts and mitochondria. They include the most characterized GroEL/GroES complex from Escherichia coli and CPN60/CPN10 from Thermus thermophilus. The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya.
3D Structures of Chaperonin
Update June 2011
Group I
Large subunit
3m6c – MtGroEL1 apical domain – Mycobacterium tuberculosis
1sjp – MtGroEL2 residues 42-539
3fbh, 2eu1, 1j4z, 1kpo, 1oel, 1grl, 2yey – EcGroEL (mutant) - Escherichia coli
3e76, 2nwc, 1xck, 1ss8 – EcGroEL
3c9v, 3cau – EcGroEL – Cryo EM
2c7e, 1gr5 - EcGroEL (mutant) – Cryo EM
1kp8 - EcGroEL (mutant) + ATP
1sx3 - EcGroEL + ATP
1sx4 - EcGroEL + ADP
1mnf – EcGroEL + polypeptide
2cgt – EcGroEL + capsid assbly protein GP31 – EM
1fy9, 1fya, 1kid – EcGroEL apical domain (mutant)
1srv – TtCPN60 apical domain - Thermus thermophilus
1iok – CPN60 – Paracoccus denitrificans
Small subunit
3nx6 – GroES residues 40-134 (mutant) – Xanthomonas oryzae
1wnr – TtCPN10 residues 1-94
1p3h, 1hx5 – MtCPN10
1p82, 1p83 - MtCPN10 residues 1-25 - NMR
1egs - GroES residues 19-27 - NMR
Large + small subunit
1svt, 1pcq - EcGroEL + GroES
1pf9, 1aon - EcGroEL + GroES + ADP
2c7c, 2c7d - EcGroEL + GroES – Cryo EM
1gru - EcGroEL + GroES + ATP + ADP – Cryo EM
1we3 – TtCPN60 + CPN10
1wf4 - TtCPN60 + CPN10 + ADP
Group II
3izh, 3izi, 3izj, 3izk, 3izl, 3izm, 3izn, 3los, 3iyf – MmCPN – Methanococcus maripaludis – EM
3kfb, 3kfe, 3kfk – MmCPN
1q2v, 1q3r – TkCPN α subunit (mutant) – Thermococcus KS-1
1q3q - TkCPN α subunit (mutant) + AMP-PNP
1q3s - TkCPN α subunit (mutant) + ADP
CCT
2xsm – bCPN CCT – bovine
3iyg - bCPN CCT – Cryo EM
3ktt - bCPN CCT β subunit – Cryo EM
1gml, 1gn1 - CPN CCT γ subunit apical domain – mouse
Hsp33
3m7m, 1hw7 – EcCPN Hsp33 N-terminal
1xjh - EcCPN Hsp33 C terminal - NMR
1vq0 - CPN Hsp33 – Thermotoga maritime
1vzy - CPN Hsp33 (mutant) – Bacillus subtilis
Thermosome
1a6d - TaTherm α+β subunits – Thermoplasma acidophilum
1a6e - TaTherm α+β subunits + ADP
1ass, 1asx - TaTherm α apical domain
1e0r – TaTherm β apical domain
3ko1 – Therm – Acidianus tengchongensis
1lep – CPN-10 – Mycobacterium leprae
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