Ionotropic Glutamate Receptors
From Proteopedia
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[[3om0]], [[3om1]] – rGluK5 N-terminal domain | [[3om0]], [[3om1]] – rGluK5 N-terminal domain | ||
+ | ===NMDA receptor=== | ||
+ | [[3jpy]], [[3jpw]] – rNMDA subunit ε2 N-terminal domain (mutant)<br /> | ||
+ | [[2a5t]] - rNMDA subunits NR1 and NR2A ligand-binding domains<br /> | ||
+ | [[2a5s]] - rNMDA subunits NR1 and NR2A ligand-binding domains + Glu | ||
Revision as of 06:28, 7 June 2011
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This article was developed based on lectures given in Chemistry 543 by Prof. Clarence E. Schutt at Princeton University.
3D structures of glutamate receptor
Ionotropic glutamate receptor 0
2pyy - IGluR2 ligand-binding domain + Glu – Nostoc punctiforme
Ionotropic glutamate receptor 2
3n6v, 3o2j - rIGluR2 N-terminal domain (mutant) – rat
3hsy, 3h5v, 3h5w - rIGluR2 N-terminal domain
2wjw, 2wjx – hIGluR2 N-terminal domain - human
3rn8, 3rnn – hIGluR2 ligand-binding domain + potentiator
3bki - rIGluR2 ligand-binding domain + inhibitor
1fto - rIGluR2 ligand-binding domain
GluR2 positive allosteric modulator complex
2xhd - hIGluR2 ligand-binding domain + positive allosteric modulator + Glu
2al4, 1p1o - rIGluR2 ligand-binding domain (mutant) + positive allosteric modulator
2xx8, 2xx7, 2xx9, 2xxh, 2xxi, 3lsf, 3h6t, 3h6u, 3h6v, 3h6w, 3bbr - rIGluR2 ligand-binding domain (mutant) + positive allosteric modulator + Glu
3pmv, 3pmw, 3pmx, 3o28, 3o29, 3o2a, 3o6g, 3o6h, 3o6i, 3m3l, 3lsl - rIGluR2 ligand-binding domain + positive allosteric modulator + Glu
1mm6, 1mm7 - rIGluR2 ligand-binding domain + positive allosteric modulator
3ijo, 3ijx, 3ik6, 3il1, 3ilt, 3ilu - rIGluR2 + positive allosteric modulator + Glu
GluR2 antagonist complex
3r7x - hIGluR2 + antagonist
3kgc, 3kg2, 2cmo - rIGluR2 ligand-binding domain + antagonist + Glu
3h03, 3h06, 3b7d, 1n0t, 1ftl - rIGluR2 ligand-binding domain + antagonist
1lb9 - rIGluR2 ligand-binding domain (mutant) + antagonist
GluR2 agonist complex
3rtf, 3rtw, 3pd8, 3pd9, 3bft, 3bfu, 1wvj, 1syh, 1syi, 1ms7, 1mqd, 1nnp, 1nnk, 1m5b, 1m5c, 1m5d, 1m5e, 1m5f, 1ftm - rIGluR2 ligand-binding domain + agonist
3b6t, 2al5, 2anj, 1p1q, 1p1u, 1p1w, 1lb8 - rIGluR2 ligand-binding domain (mutant) + agonist
1lbc - rIGluR2 ligand-binding domain (mutant) + agonist + Glu
2p2a - rIGluR2 ligand-binding domain + agonist + Glu
GluR2 partial agonist complex
1y1m, 2aix, 1y1z, 1y20, 1mqg, 1mqh, 1mqi, 1mqj, 1mxu, 1mxv, 1mxw, 1mxx, 1mxy, 1mxz, 1my0, 1my1, 1my2, 12my3, 1my4, 1fw0, 1ftk, 1gr2 - rIGluR2 ligand-binding domain + partial agonist
1xhy, 1p1n, 1lbb - rIGluR2 ligand-binding domain (mutant) + partial agonist
GluR2 ligand complex
3dp6, 2uxa, 2i3v, 2i3w, 1ftj - rIGluR2 ligand-binding domain + Glu
3b6q, 3b6w, 2gfe - rIGluR2 ligand-binding domain (mutant) + Glu
Ionotropic glutamate receptor 3
3o21, 3p3w – rIGluR3 N-terminal domain
3m3k – rIGluR3 ligand-binding domain
3rt6, 3rt8, 3dp4 – rIGluR3 ligand-binding domain + agonist
3m3f – rIGluR3 ligand-binding domain + allosteric modulator
3dln - rIGluR3 ligand-binding domain + Glu
Ionotropic glutamate receptor 4
3epe, 3fas - rIGluR4 ligand-binding domain + Glu
3kei – rIGluR4 ligand-binding domain (mutant) + Glu
3kfm - rIGluR4 ligand-binding domain (mutant) + partial agonist
3en3 - rIGluR4 ligand-binding domain + partial agonist
3fat – rIGluR4 ligand-binding domain + agonist
Ionotropic glutamate receptor 5
3fuz, 2zns – hIGluR5 ligand-binding domain + Glu
1txf - rIGluR5 ligand-binding domain + Glu
2ojt - rIGluR5 + anion
3fv1, 3fv2, 3fvg, 3fvk, 3fvn, 3fvo, 2znt, 2znu - hIGluR5 ligand-binding domain + agonist
3c31, 3c32, 3c33, 3c34, 3c35, 3c36 - rIGluR5 ligand-binding domain + ion
2wky, 3gba, 3gbb, 2pbw, 2f34, 2f35, 2f36 – rIGluR5 ligand-binding domain + agonist
2qs1, 2qs2, 2qs3, 2qs4 - rIGluR5 ligand-binding domain (mutant) + agonist
1vso - rIGluR5 ligand-binding domain + antagonist
Ionotropic glutamate receptor 6
3h6g, 3h6h – rIGluR6 N-terminal domain
3g3f, 1sd3, 1s50, 1s7y – rIGluR6 ligand-binding domain + Glu
3g3g, 3g3h, 3g3i, 3g3j, 3g3k, 2i0b, 2i0c - rIGluR6 ligand-binding domain (mutant) + Glu
1s9t – rIGluR6 ligand-binding domain + positive allosteric modulator
1tt1 – rIGluR6 ligand-binding domain + partial agonist
Metabotropic glutamate receptor 1
1ewt, 1ewv - rMGluR1 ligand-binding domain
3ks9 – hMGluR1 (mutant) + antagonist
1isr, 1ewk – rMGluR1 ligand-binding domain + Glu
1iss - rMGluR1 ligand-binding domain + antagonist
Metabotropic glutamate receptor 3
2e4u – hMGluR3 ligand-binding domain (mutant) + Glu
2e4v, 2e4w, 2e4x, 2e4y, 2e4z - hMGluR3 ligand-binding domain (mutant) + agonist
Metabotropic glutamate receptor 5
3lmk – hMGluR5 ligand-binding domain (mutant) + positive allosteric modulator + Glu
Metabotropic glutamate receptor 7
3mq4 – hMGluR7 ligand-binding domain + antagonist
Ionotropic kainate receptor 1
1ycj – rGluK1 ligand-binding domain + Glu
Ionotropic kainate receptor 2
2xxr – rGluK2 ligand-binding domain + Glu
2xxu, 2xxx – rGluK2 ligand-binding domain (mutant) + Glu
2xxt – rGluK2 ligand-binding domain + partial agonist
2xxv, 2xxy – rGluK2 ligand-binding domain (mutant) + partial agonist
1yae - rGluK2 ligand-binding domain + agonist
Ionotropic kainate receptor 3
3olz – rGluK3 N-terminal domain
Ionotropic kainate receptor 5
3om0, 3om1 – rGluK5 N-terminal domain
NMDA receptor
3jpy, 3jpw – rNMDA subunit ε2 N-terminal domain (mutant)
2a5t - rNMDA subunits NR1 and NR2A ligand-binding domains
2a5s - rNMDA subunits NR1 and NR2A ligand-binding domains + Glu
Additional Resources
For additional information on the Symmetry of the Glutamate Receptor, See: Glutamate Receptor Symmetry Analysis
For Additional Information, See: Membrane Channels & Pumps
For Additional Information, See: Alzheimer's Disease
References
- ↑ 1.0 1.1 1.2 Jin R, Clark S, Weeks AM, Dudman JT, Gouaux E, Partin KM. Mechanism of positive allosteric modulators acting on AMPA receptors. J Neurosci. 2005 Sep 28;25(39):9027-36. PMID:16192394 doi:25/39/9027
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Sobolevsky AI, Rosconi MP, Gouaux E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature. 2009 Dec 10;462(7274):745-56. Epub . PMID:19946266 doi:10.1038/nature08624
- ↑ 3.0 3.1 3.2 3.3 Purcell AE, Jeon OH, Zimmerman AW, Blue ME, Pevsner J. Postmortem brain abnormalities of the glutamate neurotransmitter system in autism. Neurology. 2001 Nov 13;57(9):1618-28. PMID:11706102
- ↑ Welsh JP, Ahn ES, Placantonakis DG. Is autism due to brain desynchronization? Int J Dev Neurosci. 2005 Apr-May;23(2-3):253-63. PMID:15749250 doi:10.1016/j.ijdevneu.2004.09.002
- ↑ Zuo J, De Jager PL, Takahashi KA, Jiang W, Linden DJ, Heintz N. Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene. Nature. 1997 Aug 21;388(6644):769-73. PMID:9285588 doi:10.1038/42009
- ↑ Rubenstein JL, Merzenich MM. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav. 2003 Oct;2(5):255-67. PMID:14606691
- ↑ Jin R, Singh SK, Gu S, Furukawa H, Sobolevsky AI, Zhou J, Jin Y, Gouaux E. Crystal structure and association behaviour of the GluR2 amino-terminal domain. EMBO J. 2009 Jun 17;28(12):1812-23. Epub 2009 May 21. PMID:19461580 doi:10.1038/emboj.2009.140
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