GTP-binding protein

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<br />
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== 3D Structures of GTP-binding protein ==
== 3D Structures of GTP-binding protein ==
 +
 +
''Updated November 2011''
===GTP-binding protein===
===GTP-binding protein===
[[3r7w]] – yGtr1 + Gtr2 – yeast<br />
[[3r7w]] – yGtr1 + Gtr2 – yeast<br />
-
[[2dpx]] – hRad GTPase domain - human<br />
+
[[2eki]] – hGBP TGS domain – NMR - human<br />
[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
[[2qtf]] – SsHflx<br />
[[2qtf]] – SsHflx<br />
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[[2nzj]] – hRem1 + GDP<br />
[[2nzj]] – hRem1 + GDP<br />
[[3cbq]] – hRem2 + GDP<br />
[[3cbq]] – hRem2 + GDP<br />
 +
[[3q85]] – hRem2 G domain + GTP analog<br />
[[2cjw]], [[2ht6]], [[2g3y]] – hGem G domain + GDP<br />
[[2cjw]], [[2ht6]], [[2g3y]] – hGem G domain + GDP<br />
[[2ohf]] – hOla1 + AMP-PCP<br />
[[2ohf]] – hOla1 + AMP-PCP<br />
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[[1xts]] - hRheB + GTP<br />
[[1xts]] - hRheB + GTP<br />
[[1xtr]] - hRheB + GPPNHP<br />
[[1xtr]] - hRheB + GPPNHP<br />
 +
[[1e0a]] – hGBP (mutant) + GIP<br />
 +
[[2b8w]], [[2d4h]] – hGBP N terminal + GMP<br />
 +
[[2b92]] - hGBP N terminal + GDP<br />
 +
[[2bc9]] - hGBP N terminal + GPPNHP<br />
[[3kxi]], [[2qth]] – SsHflx + GDP<br />
[[3kxi]], [[2qth]] – SsHflx + GDP<br />
[[3ieu]] – EcERA + GDP <br />
[[3ieu]] – EcERA + GDP <br />
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[[1ky2]] – yPt7 + GPPNHP<br />
[[1ky2]] – yPt7 + GPPNHP<br />
[[1ky3]] – yPt7 + GDP<br />
[[1ky3]] – yPt7 + GDP<br />
 +
[[3rwm]], [[3rwo]] – yPt32 + GPPNHP<br />
[[1ek0]] – yPt51 + GPPNHP<br />
[[1ek0]] – yPt51 + GPPNHP<br />
[[2hjg]] – BsEngA + GDP<br />
[[2hjg]] – BsEngA + GDP<br />
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[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
[[1m2o]] – ySar1 + protein transport protein sec23<br />
[[1m2o]] – ySar1 + protein transport protein sec23<br />
 +
[[3syn]] – BsFlhf + ATP-binding protein
===Ras-related GTP-binding protein===
===Ras-related GTP-binding protein===
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[[2l0x]] – Rheb + GDP – rat<br />
[[2l0x]] – Rheb + GDP – rat<br />
[[2gjs]] – hRad1 + GDP<br />
[[2gjs]] – hRad1 + GDP<br />
 +
[[3q72]], [[3q7p]], [[3q7q]] – hRad G-domain + GTP analog<br />
 +
[[2dpx]] – hRad GTPase domain<br />
[[2gf0]] – hDiRas1 + GDP<br />
[[2gf0]] – hDiRas1 + GDP<br />
[[2erx]] – hDiRas2 + Pi + GDP<br />
[[2erx]] – hDiRas2 + Pi + GDP<br />
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[[2j1l]] – hRhoD
[[2j1l]] – hRhoD
-
===Ras-related GTP-binding protein complex with nucleotide===
+
===Rho-related GTP-binding protein complex with nucleotide===
[[2cls]] – hRho6 + GTP<br />
[[2cls]] – hRho6 + GTP<br />
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[[1an0]] - hCdc42 + GDP<br />
[[1an0]] - hCdc42 + GDP<br />
-
===Ras-related GTP-binding protein complex with protein===
+
===Rho-related GTP-binding protein complex with protein===
[[2v55]] – hRhoE + Rho-associated protein kinase<br />
[[2v55]] – hRhoE + Rho-associated protein kinase<br />
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[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3<br />
[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3<br />
[[1gzs]] – Cdc42 + guanine nucleotide exchange factor – ''Salmonella typhimurium''<br />
[[1gzs]] – Cdc42 + guanine nucleotide exchange factor – ''Salmonella typhimurium''<br />
 +
[[2kb0]] - hCdc42 (mutant)<br />
 +
[[1kz7]] - hCdc42 + guanine nucleotide exchange factor<br />
 +
[[1kzg]] - hCdc42 (mutant) + guanine nucleotide exchange factor (mutant)<br />
 +
[[2dfk]] – hCdc42 + collybistin II<br />
 +
[[2wm9]], [[2wmn]], [[2wmo]] - hCdc42 + DOCK9<br />
 +
[[3eg5]] - hCdc42 + protein diaphanous homolog 1 + GMPPNP<br />
 +
[[3gcg]] - hCdc42 + MAP<br />
 +
[[3n3v]] - hCdc42 + AMP-protein transferase<br />
 +
[[1nf3]] - hCdc42 + Par6<br />
 +
[[2ase]] - hCdc42 (mutant) - NMR<br />
[[1ki1]] – hCdc42 + intersectin long form<br />
[[1ki1]] – hCdc42 + intersectin long form<br />
[[1ees]] – hCdc42 + MapK3 peptide - NMR<br />
[[1ees]] – hCdc42 + MapK3 peptide - NMR<br />

Revision as of 07:17, 30 November 2011

Image:2nzj.png
Crystal Structure of GTP-binding protein Rem1 complex with nucleotide 2nzj

Template:STRUCTURE 2nzj

GTP-binding proteins or G proteins are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: heterotrimeric G proteins and small GTPases. The images at the left and at the right correspond to one representative G protein, i.e. the crystal structure of human GTP-binding protein complex with nucleotide (2nzj). See details on GTP-binding protein LpeD in Ribosomal back translocase.

Contents






3D Structures of GTP-binding protein

Updated November 2011

GTP-binding protein

3r7w – yGtr1 + Gtr2 – yeast
2eki – hGBP TGS domain – NMR - human
3kxk, 3kxl – SsHflx (mutant) - Sulfolobus solfataricus
2qtf – SsHflx
1ega – EcERA – Escherichia coli
2dyk – TtEngA N terminal – Thermus thermophilus - Cryo EM
3cb4 - EcLepA
2ywe – AaLepA
1sul – BsYsxC - Bacillus subtilis
2dwq – TtYchF
1udx – TtObg
1wxq – GBP – Pyrococcus horikoshii
1ni3 – YchF – Schizosaccharomyces pombe

GTP-binding protein complex with nucleotide

2nzj – hRem1 + GDP
3cbq – hRem2 + GDP
3q85 – hRem2 G domain + GTP analog
2cjw, 2ht6, 2g3y – hGem G domain + GDP
2ohf – hOla1 + AMP-PCP
1xtq – hRheB + GDP
1xts - hRheB + GTP
1xtr - hRheB + GPPNHP
1e0a – hGBP (mutant) + GIP
2b8w, 2d4h – hGBP N terminal + GMP
2b92 - hGBP N terminal + GDP
2bc9 - hGBP N terminal + GPPNHP
3kxi, 2qth – SsHflx + GDP
3ieu – EcERA + GDP
3iev – AaERA + RNA + Mg-GNP – Aquifex aeolicus
1x1l – TtERA + RNA – Cryo EM
2ywf – AaLepA + GMP-PNP
2ywg - AaLepA + GTP
2ywh - AaLepA + GDP
1yzn – yPt1 + GPPNHP
1ky2 – yPt7 + GPPNHP
1ky3 – yPt7 + GDP
3rwm, 3rwo – yPt32 + GPPNHP
1ek0 – yPt51 + GPPNHP
2hjg – BsEngA + GDP
1svi – BsYsxC + GDP
1svw – BsYsxC + GMPPNP
1lnz – BsObg + GTP
2dby – TtYchF + GDP
1wf3 – Tt1341 + GNP
2gao - hSar1A + GDP
2fa9 – ChSar1B (mutant) + GDP – Chinese hamster
2fmx - ChSar1B + GDP
1byu – Ran + GDP - dog


GTP-binding protein complex with protein

1ees – hCdc42 + MapK3 peptide - NMR
1x18 – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM
3deg – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM
3cue – yPt1 + transport protein subunits
2bcg, 1ukv - yPt1 + secretory pathway GDP-dissociation inhibitor
3cpj – yPt31 + Rab GDP-dissociation inhibitor
1m2o – ySar1 + protein transport protein sec23
3syn – BsFlhf + ATP-binding protein

Ras-related GTP-binding protein

3llu – hC nucleotide-binding domain

Ras-related GTP-binding protein complex with nucleotide

2l0x – Rheb + GDP – rat
2gjs – hRad1 + GDP
3q72, 3q7p, 3q7q – hRad G-domain + GTP analog
2dpx – hRad GTPase domain
2gf0 – hDiRas1 + GDP
2erx – hDiRas2 + Pi + GDP
1x3s – hRab-18 + GPPNHP
1yu9 - hRab-4A + GPPNHP
2atx – hTc10 + GPPNHP
1g16 – ySec4 + GDP
1g17 - ySec4 + GIP

Ras-related GTP-binding protein complex with protein

3kuc – hRap-1A + proto oncogene Ser/Thr protein kinase
3cf6 - hRap-1A + Rap guanine nucleotide exchange factor 4
3brw - hRap-1B + Rap GTPase-activating protein
1z0k – hRab-4 + rabenosyn-5

Interferon-induced GTP-binding protein

3ljb – hMx1 stalk region

Rho-related GTP-binding protein

2j1l – hRhoD

Rho-related GTP-binding protein complex with nucleotide

2cls – hRho6 + GTP
2fv8 - hRhoB + GDP
2gcn – hRhoC + GDP
2gco – hRhoC + GPPNHP
1z2c - hRhoC (mutant) + GMPPNP
2gcp – hRhoC + GSP
1m7b - hRhoE + GTP
1gwn - RhoE + GTP - mouse
1a4r - hCdc42 (mutant) + GDP
1an0 - hCdc42 + GDP

Rho-related GTP-binding protein complex with protein

2v55 – hRhoE + Rho-associated protein kinase
3q3j – hRho6 + plexin-A2 nucleotide-binding domain
2rex – hRho6 + plexin-B1
1cc0 – hRhoA + GDP-dissociation inhibitor + GDP
3a58 – yRho1 (mutant) + exocyst complex component Sec3
1gzs – Cdc42 + guanine nucleotide exchange factor – Salmonella typhimurium
2kb0 - hCdc42 (mutant)
1kz7 - hCdc42 + guanine nucleotide exchange factor
1kzg - hCdc42 (mutant) + guanine nucleotide exchange factor (mutant)
2dfk – hCdc42 + collybistin II
2wm9, 2wmn, 2wmo - hCdc42 + DOCK9
3eg5 - hCdc42 + protein diaphanous homolog 1 + GMPPNP
3gcg - hCdc42 + MAP
3n3v - hCdc42 + AMP-protein transferase
1nf3 - hCdc42 + Par6
2ase - hCdc42 (mutant) - NMR
1ki1 – hCdc42 + intersectin long form
1ees – hCdc42 + MapK3 peptide - NMR
1doa - hCdc42 + GDP-dissociation inhibitor

Rac-like GTP-binding protein

2wbl – AtArac2 + Rho of plant guanine nucleotide exchange factor 8 – Arabidopsis thaliana
3bwd – AtArac6
2nty – AtArac5 + prone8
2j0v – AtArac7 (mutant)

Rab-related GTP-binding protein

2ys8 – hRabJ DNAJ domain – NMR

Flagella-associated GTP-binding protein

2px0 – BsFlhF + GMP-PNP
2px3 – BsFlhF + GTP

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